Interictal burden attributable to episodic headache: findings from the Eurolight project
Interictal burden attributable to episodic headache: findings from the Eurolight project
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DOI：
10.1186/s10194-016-0599-8
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发表时间：
2016-02-16
影响因子：
7.4
通讯作者：
Steiner, Timothy J.
中科院分区：
文献类型：
--
作者：
Lampl, Christian;Thomas, Hallie;Steiner, Timothy J.
背景资料：大多数原发性头痛是发作性的，大多数对头痛所致的严重残疾负担的估计来自于侧重于偏头痛和紧张型头痛（TTH）的发作性亚型的流行病学数据。这些疾病直接但间歇性地引起症状负担。然而，患有这些疾病的人在发作之间可能并不是无症状的。我们分析了Eurolight数据集interictal burners.Methods：Eurolight是一个横断面调查，采用修改后的整群抽样从成年人口（18-65岁）在10个国家的欧盟。我们使用了9个数据。问卷包括头痛诊断问题的基础上ICHD-II和几个问题集解决的影响，包括发作间期和累积burners.Results：有6455名参与者头痛（男性2444 [37.9%]）。26.0%的偏头痛患者和18.9%的TTH患者报告了发作间隙症状：偏头痛患者的发作间隙焦虑为10.6%，回避（生活方式妥协）为14.8%，两者均比TTH患者常见得多（分别为3.1%[OR 3.8]和4.7%[OR 3.5]）。偏头痛发作间期的平均时间为317天/年，TTH为331天/年。那些“很少”或“从不”控制头痛的人（偏头痛15.2%，TTH 9.6%）的发作间期焦虑，回避和其他发作间期症状的几率显着增加。在偏头痛患者中，发作间期焦虑随着头痛强度和频率的增加而显著增加，回避程度较低，但仍然显著。生产时间的损失与焦虑和回避的高OR（高达5.3）相关。三分之一（32.9%）的偏头痛患者和四分之一（26.7%）的TTH患者（差异：p < 0.0001）不愿意告诉别人他们的头痛。每种疾病中约有10%的人感到家人和朋友不理解他们的头痛。近12%的偏头痛患者报告他们的雇主和同事没有。关于累积负担，11.8%的人报告说，他们做得不太好，因为头痛，5.9%的收入减少和7.4%，他们的职业生涯suffered.Conclusions：发作间期的负担在那些发作性头痛是常见的，更是偏头痛比TTH。有些因素有可能产生深远的影响。如果头痛负担的描述是完整的，需要新的方法来衡量发作间期的负担。
Background: Most primary headaches are episodic, and most estimates of the heavy disability burden attributed to headache derive from epidemiological data focused on the episodic subtypes of migraine and tension-type headache (TTH). These disorders give rise directly but intermittently to symptom burden. Nevertheless, people with these disorders may not be symptom-free between attacks. We analysed the Eurolight dataset for interictal burden.Methods: Eurolight was a cross-sectional survey using modified cluster sampling from the adult population (18-65 years) in 10 countries of the European Union. We used data from nine. The questionnaire included headache-diagnostic questions based on ICHD-II and several question sets addressing impact, including interictal and cumulative burdens.Results: There were 6455 participants with headache (male 2444 [37.9 %]). Interictal symptoms were reported by 26.0 % of those with migraine and 18.9 % with TTH: interictal anxiety by 10.6 % with migraine and avoidance (lifestyle compromise) by 14.8 %, both much more common than in TTH (3.1 % [OR 3.8] and 4.7 % [OR 3.5] respectively). Mean time spent in the interictal state was 317 days/year for migraine, 331 days/year for TTH. Those who were "rarely" or "never" in control of their headaches (migraine 15.2 %, TTH 9.6 %) had significantly raised odds of interictal anxiety, avoidance and other interictal symptoms. Among those with migraine, interictal anxiety increased markedly with headache intensity and frequency, avoidance less so but still significantly. Lost productive time was associated with high ORs (up to 5.3) of anxiety and avoidance. A third (32.9 %) with migraine and a quarter (26.7 %) with TTH (difference: p < 0.0001) were reluctant to tell others of their headaches. About 10 % with each disorder felt families and friends did not understand their headaches. Nearly 12 % with migraine reported their employers and colleagues did not. Regarding cumulative burden, 11.8 % reported they had done less well in education because of headache, 5.9 % reported reduced earnings and 7.4 % that their careers had suffered.Conclusions: Interictal burden in those with episodic headache is common, more so in migraine than TTH. Some elements have the potential to be profoundly consequential. New methodology is needed to measure interictal burden if descriptions of headache burden are to be complete.