ANTI-INTERLEUKIN-4 TREATMENT DIMINISHES SECRETION OF TH2 CYTOKINES AND INHIBITS HEPATIC-FIBROSIS IN MURINE SCHISTOSOMIASIS-JAPONICA
ANTI-INTERLEUKIN-4 TREATMENT DIMINISHES SECRETION OF TH2 CYTOKINES AND INHIBITS HEPATIC-FIBROSIS IN MURINE SCHISTOSOMIASIS-JAPONICA
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DOI：
10.1111/j.1365-3024.1995.tb00972.x
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发表时间：
1995-02-01
影响因子：
2.2
通讯作者：
COX, TM
中科院分区：
文献类型：
--
作者：
CHEEVER, AW;FINKELMAN, FD;COX, TM
日本血吸虫感染小鼠经白介素4(IL-4)治疗后，在体外可明显抑制抗原刺激的脾细胞分泌Th2细胞因子IL-4和IL-5，但增强Th1细胞因子干扰素-γ的分泌。IL-2的分泌未受影响。在感染10周后，抗IL-4治疗的小鼠的肝纤维化明显减轻，而肝脏中日本血吸虫虫卵周围的肉芽肿大小轻微到中度增大。每对蠕虫在组织和粪便中的产卵量在治疗和未治疗的小鼠中没有显著差异。提示Th2细胞因子反应在血吸虫性肝纤维化的发生中起重要作用。
Anti-interleukin-4 (IL-4) treatment of Schistosoma japonicum-infected mice markedly inhibited in vitro secretion of the Th2 cytokines IL-4 and IL-5 from antigen-stimulated spleen cells, but enhanced the secretion of the Th1 cytokine IFN-gamma. IL-2 secretion was unaffected. Hepatic fibrosis was markedly diminished in anti-IL-4-treated-mice at ten weeks of infection while granulomas around S. japonicum eggs in the livers were slightly-to-moderately increased in size. The number of eggs per worm pair in the tissues and feces did not differ significantly in treated and untreated mice. These findings suggest that Th2 cytokine responses are important in the genesis of schistosomal hepatic fibrosis.