INVITRO STUDIES INTO THE USE OF DENTURE BASE AND SOFT LINER MATERIALS AS CARRIERS FOR DRUGS IN THE MOUTH
INVITRO STUDIES INTO THE USE OF DENTURE BASE AND SOFT LINER MATERIALS AS CARRIERS FOR DRUGS IN THE MOUTH
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DOI：
10.1111/j.1365-2842.1981.tb00486.x
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发表时间：
1981-01-01
影响因子：
2.9
通讯作者：
ADDY, M
中科院分区：
文献类型：
--
作者：
ADDY, M
研究了增塑和聚合的丙烯酸酯作为载药和释药材料的潜力。将浓度分别为2%、5%和10%的醋酸氯己定分别加入到热固化和冷固化的丙烯酸酯粉末相中，并制成丙烯酸凝胶软衬。初步的生物测试表明，这三种材料在抗菌水平上都有类似的释放。用分光光度法和琼脂扩散法对氯己定在水中的释放量进行了测定，结果表明，氯己定的释药时间随氯己定浓度的增加而延长。当外加剂质量分数为10%时，聚合体和增塑体的释放量均在100d以上。对聚丙烯酸酯的抛光表面和断裂表面的光学和扫描电子显微镜观察表明，洗必泰分布在材料的整个基质中。在水中浸泡后，基质中出现孔洞，特别是在表面区。丙烯酸凝胶软衬的切片显示洗必泰以颗粒状物质分布。浸泡在水中会导致材料的空泡化，在较高浓度下，材料会明显破裂。
The potential of plasticized and polymerized acrylics to carry and release medicaments was investigated. Chlorhexidine acetate was incorporated at concentrations of 2, 5 and 10% into the powder phase of heat and cold cured acrylics and an acrylic gel soft liner. A preliminary bioassay demonstrated comparable release at anti‐bacterial levels from all three materials. Spectrophotometric and agar diffusion measurements of the chlorhexidine released into water showed the duration increased with the concentration of chlorhexidine incorporated. At 10% admixture the release from the polymerized and plasticized acrylics was in excess of 100 days. Light and scanning electron microscopy of polished and fractured surfaces of the polymerized acrylic showed the chlorhexidine distributed throughout the matrix of the materials. Following soaking in water, holes appeared in the matrix, particularly in the surface zones. Sections of the acrylic gel soft liner demonstrated chlorhexidine distributed as particulate material. Soaking in water caused vacuolation of the material and at higher concentrations material break‐up was apparent.