Research progress on the forkhead box C1.
Research progress on the forkhead box C1.
复制标题
叉头盒C1的研究进展
DOI：
10.18632/oncotarget.22527
复制
发表时间：
2018-02-23
期刊：
影响因子：
--
通讯作者：
Du G
中科院分区：
文献类型：
--
作者：
Wang J;Li W;Zheng X;Pang X;Du G
FOXC1是FOX家族的重要成员，在增殖、分化、凋亡、迁移、侵袭、代谢和寿命等生物学过程中发挥重要作用。在这里，我们重点关注 FOXC1 的作用及其在癌症中的机制。 FOXC1促进了多种癌症的进展，如乳腺癌（尤其是基底样乳腺癌）、肝细胞癌、胃癌等。 FOXC1 还被发现与癌症的耐药性有关。 FOXC1通过增加MMP7、NEDD9和Snail的表达来促进癌症转移。 FOXC1 通过介导 NF-κB、MST1R 和 KLF4 的表达来增加癌症的增殖和侵袭。 FOXC1 通过调节 FGF19 和 MSX1 的表达与发育相关。最近，发现FOXC1通过介导Gli2、CXCL12、SCF、NFATC1、BMP和Myh7的表达而成为干细胞生态位或干细胞发育所必需的。总体而言，FOXC1通过多种机制发挥其功能，并可用作疾病的潜在生物标志物。
FOXC1 is a vital member of FOX families which play important roles in biological processes including proliferation, differentiation, apoptosis, migration, invasion, metabolism, and longevity. Here we are focusing on roles of FOXC1 and their mechanisms in cancers. FOXC1 promoted progress of many cancers, such as breast cancer (especially basal-like breast cancer), hepatocellular carcinoma, gastric cancer and so on. FOXC1 was also found to be associated with drug resistance of cancers. FOXC1 promoted metastasis of cancers by increasing expression of MMP7, NEDD9 and Snail. Proliferation and invasion of cancers were increased by FOXC1 by mediating NF-κB, MST1R and KLF4 expression. FOXC1 was associated with development by regulating expression of FGF19 and MSX1. Recently, FOXC1 was found to be required for niche of stem cells or development of stem cells by mediating expression of Gli2, CXCL12, SCF, NFATC1, BMP and Myh7. Overall, FOXC1 exerts its functions by many mechanisms and may be used as a potential biomarker for diseases.