A cluster-randomised trial to compare home-based with health facility-based antiretroviral treatment in Uganda: study design and baseline findings.
A cluster-randomised trial to compare home-based with health facility-based antiretroviral treatment in Uganda: study design and baseline findings.
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DOI：
10.2174/1874613600701010021
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Jaffar, Shabbar
中科院分区：
文献类型：
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作者：
Amuron, Barbara;Coutinho, Alex;Jaffar, Shabbar
非洲抗逆转录病毒治疗的扩大化进展迅速，但证据基础有限。我们报告了一项大型实用整群随机试验的基线结果，该试验比较了不同的 ART 治疗策略。该试验被纳入正常的医疗服务提供中。该研究招募了 1453 名受试者。被招募的女性 (71%) 明显多于男性 (29%)。目前的 WHO HIV 临床分期在男性和女性之间没有显着差异：分别有 58% 和 53% 处于 WHO III 期或 IV 期 (p=0.9)。男性中位 CD4 计数 (IQR) x 106 个细胞/升为 98 (28, 160)，女性为 111 (36, 166)。 64% 的女性和 61% 的男性血浆病毒载量≥100,000 拷贝。基线特征不随时间变化。前来接受治疗的男性明显少于女性。男性和女性均处于晚期，CD4 计数中位数非常低，血浆病毒载量较高。
The scale-up of antiretroviral therapy is progressing rapidly in Africa but with a limited evidence-base. We report the baseline results from a large pragmatic cluster-randomised trial comparing different strategies of ART delivery. The trial is integrated in normal health service delivery. 1453 subjects were recruited into the study. Significantly more women (71%) than men (29%) were recruited. The WHO HIV clinical stage at presentation did not differ significantly between men and women: 58% and 53% respectively were at WHO stage III or IV (p=0.9). Median CD4 counts (IQR) x 106 cells/l were 98 (28, 160) among men and 111 (36, 166) among women. Sixty-four percent of women and 61% men had plasma viral load > or =100,000 copies. Baseline characteristics did not change over time. Considerably fewer men than women presented for treatment. Both men and women presented at an advanced stage with very low median CD4 count and high plasma viral load.