Phenotypic Plasticity of MDSC in Cancers
Phenotypic Plasticity of MDSC in Cancers
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DOI：
10.3109/08820139.2012.673670
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Manjili, Masoud H.
中科院分区：
文献类型：
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作者：
Manjili, Masoud H.
髓系来源的抑制细胞(MDSCs)最初被报道为抗癌和其他疾病的获得性免疫反应的抑制细胞。然而，新出现的证据表明，MDSCs在一定条件下也可能支持抗肿瘤免疫反应，或者可能抑制肿瘤生长。在这篇简短的综述中，我们认为MDSCs的这种相反的功能是由于髓系细胞的表型可塑性，使它们能够产生不同形式的形态、生理状态和功能来响应环境条件。因此，可以通过免疫调节剂来操纵它们，以克服它们的免疫抑制功能。
Myeloid-derived suppressor cells (MDSCs) were initially reported as suppressor of the adaptive immune responses against cancer and other diseases. However, emerging evidence suggest that MDSCs may also support anti-tumor immune responses under certain conditions or may inhibit tumor growth. In the present mini-review, we suggest that such opposing functions of MDSCs are due to phenotypic plasticity of the myeloid cells, allowing them to produce a diverse form of morphology, physiological state, and function in response to environmental conditions. Therefore, they can be manipulated by means of immune modulators to overcome their immune suppressive function.