CELL-CYCLE CONTROL AND CANCER-CHEMOTHERAPY
CELL-CYCLE CONTROL AND CANCER-CHEMOTHERAPY
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DOI：
10.1002/jcb.240540411
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发表时间：
1994-04-01
影响因子：
4
通讯作者：
OCONNOR, PM
中科院分区：
文献类型：
--
作者：
KOHN, KW;JACKMAN, J;OCONNOR, PM
随着关于细胞周期事件如何调节的详细信息的积累，我们可以期待应用于癌症治疗的新机会。癌基因和肿瘤抑制基因的表达改变通常发生在人类癌症中，可能会损害细胞对代谢扰动或应激的反应能力。受损的细胞周期调节将使细胞易受针对特定肿瘤中存在的缺陷而定制的药物方案的药理学干预的影响。最近的研究结果，可能成为适用于治疗的审查，并考虑新的治疗策略的可能形式。 (C)1994年Wiley-Liss，Inc.*
As detailed information accumulates about how cell cycle events are regulated, we can expect new opportunities for application to cancer therapy. The altered expression of oncogenes and tumor suppressor genes that commonly occurs in human cancers may impair the ability of the cells to respond to metabolic perturbations or stress. impaired cell cycle regulation would make cells vulnerable to pharmacologic intervention by drug regimens tailored to the defects existing in particular tumors. Recent findings that may become applicable to therapy are reviewed, and the possible form of new therapeutic stratagems is considered. (C) 1994 Wiley-Liss, Inc.*