Significant suppression of myocardial 18F-fluorodeoxyglucose uptake using 24-h carbohydrate restriction and a low-carbohydrate, high-fat diet
Significant suppression of myocardial 18F-fluorodeoxyglucose uptake using 24-h carbohydrate restriction and a low-carbohydrate, high-fat diet
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DOI：
10.1016/j.jjcc.2013.05.004
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发表时间：
2013-11-01
影响因子：
2.5
通讯作者：
Sakurai, Minoru
中科院分区：
文献类型：
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作者：
Kobayashi, Yasuhiro;Kumita, Shin-ichiro;Sakurai, Minoru
目的：氟-18-脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）是评价炎症的有用工具。由于心肌FDG摄取具有不同的生理机制，因此在FDG-PET/CT评价心肌炎症时应予以抑制。在摄取抑制方案中使用诱导基于脂肪的代谢的饮食，例如低碳水化合物、高脂肪饮食（LCHF）。然而，心肌FDG摄取的完全抑制尚未建立。因此，我们评估了24小时碳水化合物限制沿着LCHF饮食与常规方案相比在抑制心肌FOG摄取方面的功效，并且还比较了这些方案之间的脂肪和葡萄糖代谢。
Objectives: F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is a useful tool for evaluating inflammation. Because, myocardial-FDG uptake occurs with diverse physiology, it should be suppressed during evaluation of myocardial inflammation by FDG-PET/CT. Diets inducing fat-based metabolism, such as a low-carbohydrate, high-fat diet (LCHF), are used in uptake-suppression protocols. However, a complete suppression of myocardial-FDG uptake has not been established. Hence, we assessed the efficacy of 24-h carbohydrate restriction along with an LCHF diet compared to that of the conventional protocol in suppressing myocardial-FOG uptake and also compared fat and glucose metabolism between these protocols.Methods: Fourteen healthy volunteers agreed to undergo >24-h carbohydrate restriction (glucose,