Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes
Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes
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DOI：
10.1016/s0014-5793(02)02294-9
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发表时间：
2002-02-27
期刊：
影响因子：
3.5
通讯作者：
Basu, J
中科院分区：
文献类型：
--
作者：
Mandal, D;Moitra, PK;Basu, J
红细胞外表面出现磷脂酰丝氨酸（PS）是其被巨噬细胞摄取的一个重要信号。我们首次报道，在叔丁基过氧化氢诱导的氧化应激下，无核的成熟人红细胞中存在的半胱天冬酶原3被激活，导致氨基磷脂转位酶受损、PS外化以及红细胞吞噬作用增强。这是首次将半胱天冬酶3的激活与翻转酶活性的抑制以及巨噬细胞对红细胞的摄取联系起来的报道。（C）2002欧洲生物化学学会联合会。由爱思唯尔科学出版社出版。保留所有权利。
The appearance of phosphatidylserine (PS) on the outer surface of red cells is an important signal for their uptake by macrophages. We report for the first time that procaspase 3 present in the anucleated mature human erythrocyte is activated under oxidative stress induced by t-butylhydroperoxide leading to impairment of the aminophospholipid translocase, PS externalization and increased erythrophagocytosis. This is the first report linking caspase 3 activation to inhibition of flippase activity and uptake of red cells by macrophages. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.