Industrial production of monoclonal antibodies and therapeutic proteins by dialysis fermentation
Industrial production of monoclonal antibodies and therapeutic proteins by dialysis fermentation
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通过透析发酵工业化生产单克隆抗体和治疗蛋白
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
H. Brunner
中科院分区：
文献类型：
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作者：
M. Comer;Michael J. Kearns;J. Wahl;M. Munster;T. Lorenz;B. Szperalski;Stefan Koch;U. Behrendt;H. Brunner
报道了一种用于哺乳动物细胞及其分泌产物的大规模生长的新的和强大的发酵方法。所描述的系统说明了常规分批发酵工艺的许多优点，但另外已显示产生超过1×107个细胞/ml的细胞密度，伴随着产物浓度的增加。
A novel and powerful fermentation method is reported for the large-scale growth of mammalian cells and their secreted products. The system described illustrates many of the advantages of conventional batch fermentation processes but in addition has been shown to yield cell densities in excess of 1×107 cells/ml with concomitant increase in product concentration.