Modifying calf lung surfactant by hexadecanol
Modifying calf lung surfactant by hexadecanol
复制标题
DOI：
10.1021/la047894b
复制
发表时间：
2005-02-01
期刊：
影响因子：
3.9
通讯作者：
Zasadzinski, JA
中科院分区：
文献类型：
--
作者：
Alonso, C;Bringezu, F;Zasadzinski, JA
单分子层的性质，如相行为，崩溃的压力，和表面粘度是由单分子层的组成。了解如何通过简单的添加剂来控制这些特性对于理解肺表面活性剂单层和设计用于治疗疾病的最佳替代表面活性剂是重要的。Infasurf是一种来自小牛肺灌洗有机提取物的替代肺表面活性剂，其性质可以通过添加十六醇（HD）以受控方式进行修改。掠入射X射线衍射表明，HD优先与二棕榈酰磷脂酰胆碱（DPPC），Infasurf的主要磷脂成分，以相同的方式在DPPC和HD的二元混合物的相互作用。HD插入DPPC链之间，这导致二维晶格的更紧密的堆积和固相的更大稳定性。这种分子重组引发宏观尺度的变化，导致在给定的表面压力和表面剪切粘度的数量级增加的固相分数大大增加。然而，塌陷压力降低，因此，膜的最小表面张力增加。
Monolayer properties such as phase behavior, collapse pressure, and surface viscosity are determined by monolayer composition. Learning how to control these properties through simple additives is important to understanding lung surfactant monolayers and to designing optimal replacement surfactants for treatment of disease. The properties of Infasurf, a replacement lung surfactant derived from calf lung lavage organic extract, can be modified in a controlled fashion by adding hexadecanol (HD). Grazing incidence X-ray diffraction shows that the HD preferentially interacts with dipalmitoylphosphatidylcholine (DPPC), the main phospholipid component of Infasurf, in the same way as in binary mixtures of DPPC and HD. HD intercalates between the DPPC chains, which leads to a tighter packing of the two-dimensional lattice and greater stability of the solid phase. This molecular reorganization triggers changes at the macroscopic scale, leading to a greatly increased solid-phase fraction at a given surface pressure and order of magnitude increases in the surface shear viscosity. However, the collapse pressure decreases, and, hence, the minimum surface tension of the film increases.