Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975-2010.
Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975-2010.
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DOI：
10.1001/jamasurg.2014.1756
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发表时间：
2015-01
期刊：
影响因子：
16.9
通讯作者：
Chang GJ
中科院分区：
文献类型：
--
作者：
Bailey CE;Hu CY;You YN;Bednarski BK;Rodriguez-Bigas MA;Skibber JM;Cantor SB;Chang GJ
自1998年以来，结直肠癌（CRC）的总体发病率一直在下降，但年轻人的CRC发病率明显上升。评估美国CRC发病率长期趋势中与年龄相关的差异。使用监测、流行病学和最终结果（SEER）CRC登记的回顾性队列研究。诊断时的年龄从20岁开始以15年为间隔进行分析。SEER*Stat用于获得癌症年发病率、年百分比变化（APC）和长期趋势的相应p值。数据来自国家癌症研究所的SEER登记处。1975年1月1日至2010年12月31日诊断为结肠癌或直肠癌的所有患者（N = 393，241）。不同年龄的CRC发病率差异。1975年至2010年间，年龄调整后的CRC总体发病率下降了0.92%。在50岁或以上的患者中，CRC的发病率稳步下降，但在年轻人中观察到相反的趋势。对于20至34岁的患者，局部、区域和远端结肠癌和直肠癌的发病率有所增加。35至49岁的直肠癌患者的发病率也有所增加。根据目前的趋势，到2030年，20至34岁患者的结肠癌和直肠癌发病率将分别增加90.0%和124.2%，35至49岁患者的发病率将分别增加27.7%和46.0%。在年轻人中诊断出的CRC发病率显著增加，老年患者的发病率下降。需要进一步的研究来确定这些趋势的原因，并确定潜在的预防和早期发现策略。
The overall incidence of colorectal cancer (CRC) has been decreasing since 1998, but there has been an apparent rise in the incidence of CRC in young adults. To evaluate age-related disparities in secular trends in CRC incidence in the United States. A retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) CRC registry. Age at diagnosis was analyzed in 15-year intervals starting at the age of 20. SEER*Stat was used to obtain the annual cancer incidence rates, annual percent change (APC), and corresponding p-values for the secular trends. Data was obtained from the National Cancer Institute’s SEER registry. All patients diagnosed with colon or rectal cancer from January 1, 1975 through December 31, 2010 (N = 393,241). Difference in CRC incidence by age. Overall age-adjusted CRC incidence rate decreased by 0.92% between 1975 and 2010. There has been a steady decline in the incidence of CRC in patients age 50 years or older, but the opposite trend has been observed for young adults. For patients 20 to 34 years of age, the incidence rate of localized, regional and distant colon and rectal cancer has increased. Increasing incidence rate was also observed for rectal cancer patients aged 35 to 49. Based on current trends, in 2030 the incidence rate for colon and rectal cancer will increase by 90.0% and 124.2% for patients 20 to 34 years of age and by 27.7% and 46.0% for patients 35 to 49 years of age. There has been a significant increase in the incidence of CRC diagnosed in young adults, with a decline in older patients. Further studies are needed to determine the cause for these trends and identify potential preventive and early detection strategies.