INDUCTION OF LEG-SHAKING, KNOCK-DOWN AND KILLING RESPONSES BY GAMMA-RAY IRRADIATION IN SHAKER MUTANTS OF DROSOPHILA-MELANOGASTER
INDUCTION OF LEG-SHAKING, KNOCK-DOWN AND KILLING RESPONSES BY GAMMA-RAY IRRADIATION IN SHAKER MUTANTS OF DROSOPHILA-MELANOGASTER
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DOI：
10.1269/jrr.36.134
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发表时间：
1995-06-01
影响因子：
2
通讯作者：
TANAKA, Y
中科院分区：
文献类型：
--
作者：
MEGUMI, T;GAMO, S;TANAKA, Y
研究了γ射线照射诱导果蝇Shaker（Sh）突变体的膜相关反应，即抖腿、击倒和杀死。突变体在γ射线照射后的敲低反应中比野生型更敏感。敲除反应存在很大的性别差异，雄性比雌性敏感，但在杀死反应中没有性别差异。雌性X染色体的性别差异大于基因剂量效应。遗传分析表明，敲低反应的敏感性是一个不完全显性性状，没有母体效应。腿抖动的反应，这是以前曾报道过的乙醚处理诱导，被证明在头删除苍蝇的Sh突变体。它被认为是最敏感的反应测试，并可能涉及的K-匕首通道的变化。击倒反应可能与腿抖动反应的扩展有关。杀死反应的原因应该不同于抖腿反应和击倒反应，因为它们之间缺乏相关性。
Induction of membrane-associated responses, a leg-shaking, a knock-down and a killing, by gamma-ray irradiation was investigated in Shaker (Sh) mutants of Drosophila melanogaster in which the gene cords for the A-current K-dagger channel. Sh mutants were more sensitive in the knock-down response after gamma-ray irradiation than wild types. There were a great amount of sex difference in the knock-down response, males being more sensitive than females, but not in the killing response. The sex difference was larger than gene dosage effect on X chromosome in females. Genetical analysis revealed that the sensitivity of the knock-down response is an incompletely dominant character without maternal effects. The leg-shaking response, which had previously been reported to be induced by ether treatment, was demonstrated in the head-removed flies of Sh mutants. It was found to be the most sensitive among the responses tested, and may involve changes in K-dagger channel. The knock-down response may be related to expansion of the leg-shaking response. The killing response should have causes different from the leg-shaking and the knock-down responses judging from the lack of correlation with them.