PERSISTENCE OF METABOLIC CONSEQUENCES IN THE PROGENY OF RATS FED A HC FORMULA IN THEIR EARLY POSTNATAL LIFE
PERSISTENCE OF METABOLIC CONSEQUENCES IN THE PROGENY OF RATS FED A HC FORMULA IN THEIR EARLY POSTNATAL LIFE
复制标题
DOI：
10.1152/ajpendo.1995.269.4.e731
复制
发表时间：
1995-10-01
影响因子：
5.1
通讯作者：
PATEL, MS
中科院分区：
文献类型：
--
作者：
VADLAMUDI, S;KALHAN, SC;PATEL, MS
第一代（1-）雄性和雌性大鼠幼仔采用高碳水化合物（HC）或高脂肪（HF）配方人工饲养，或从第4天开始由母亲（MF）喂养，并在第24天断奶，开始饲喂储备饲料。与性别匹配的对照大鼠（1-HF和1-MF）相比，1-HC大鼠在第60天出现高胰岛素血症和轻度肥胖。我们研究了母体高胰岛素血症对第二代（2-）的影响，通过组内育种。2-HC雄性和雌性大鼠在第45天出现高胰岛素血症，从第60天开始生长速率显著增加，并在第100天因肥大导致脂肪组织质量增加而变得肥胖。2-HC组大鼠肝脏和脂肪组织的脂肪生成能力显著高于对照组。因此，在产后早期喂食HC配方奶粉的第一代大鼠中发生的代谢变化不仅持续到成年，而且还会遗传给下一代。
First-generation (1-) male and female rat pups were either reared artificially on a high-carbohydrate (HC) or a high-fat (HF) formula or nursed by mother (MF) from day 4 and weaned onto a stock diet on day 24. 1-HC rats compared with sex-matched control rats (1-HF and 1-MF) were hyperinsulinemic and mildly obese by day 60. We investigated the effect of maternal hyperinsulinemia on the second generation (2-) by intragroup breeding. The 2-HC male and female rats were hyperinsulinemic on day 45, had significantly increased growth rate from similar to day 60 onward, and became obese as evidenced by increased adipose tissue mass due to hypertrophy on day 100. The lipogenic capacity of liver and adipose tissues was significantly higher in the 2-HC than in control rats. Thus the metabolic changes that occurred in the first-generation rats fed a HC formula during early postnatal life not only persisted into their adult life but were also passed on to the next generation.