Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms.
Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms.
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DOI：
10.1155/2018/8414257
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发表时间：
2018
影响因子：
--
通讯作者：
Banawas SS
中科院分区：
文献类型：
--
作者：
Banawas SS
艰难梭菌（C.艰难梭菌（difficile）是医疗保健相关性腹泻的最普遍的致病病原体。值得注意的是，在过去10年中，艰难梭菌爆发的数量随着发病率和死亡率的增加而增加。研究表明，该菌的发生和传播具有一定的规律性。对多种抗微生物药物具有抗性的艰难梭菌菌株使预防以及潜在的治疗选择复杂化。大部分C。艰难梭菌分离株仍然对甲硝唑和万古霉素敏感。C的发生率。对其他抗菌药物的艰难耐药性也有报道。大多数抗生素与C.艰难梭菌感染（CDI），如氨苄青霉素、阿莫西林、头孢菌素、克林霉素和氟喹诺酮类，仍然与CDI的最高风险相关。然而，对甲硝唑或万古霉素耐药的详细机制尚不清楚。红霉素、氟喹诺酮、利福霉素耐药的主要机制是抗生素靶位点的改变。很难本文对不同的抗菌药物进行了综述，并对C.艰难抵抗模式和他们的生存机制进行了总结。
Clostridium difficile (C. difficile) is the most prevalent causative pathogen of healthcare-associated diarrhea. Notably, over the past 10 years, the number of Clostridium difficile outbreaks has increased with the rate of morbidity and mortality. The occurrence and spread of C. difficile strains that are resistant to multiple antimicrobial drugs complicate prevention as well as potential treatment options. Most C. difficile isolates are still susceptible to metronidazole and vancomycin. Incidences of C. difficile resistance to other antimicrobial drugs have also been reported. Most of the antibiotics correlated with C. difficile infection (CDI), such as ampicillin, amoxicillin, cephalosporins, clindamycin, and fluoroquinolones, continue to be associated with the highest risk for CDI. Still, the detailed mechanism of resistance to metronidazole or vancomycin is not clear. Alternation in the target sites of the antibiotics is the main mechanism of erythromycin, fluoroquinolone, and rifamycin resistance in C. difficile. In this review, different antimicrobial agents are discussed and C. difficile resistance patterns and their mechanism of survival are summarized.
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影响因子：
11.8
作者：
Curry, Scott R.;Marsh, Jane W.;Harrison, Lee H.
通讯作者：
Harrison, Lee H.
DOI：
10.1097/ipc.0000000000000350
发表时间：
2016-01
期刊：
Infectious diseases in clinical practice (Baltimore, Md.)
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
4.9
作者：
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