Spatial and Temporal Characteristics of Error-Related Activity in the Human Brain
Spatial and Temporal Characteristics of Error-Related Activity in the Human Brain
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DOI：
10.1523/jneurosci.1313-14.2015
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发表时间：
2015-01-07
影响因子：
5.3
通讯作者：
Petersen, Steven E.
中科院分区：
文献类型：
--
作者：
Neta, Maital;Miezin, Francis M.;Petersen, Steven E.
许多研究都集中在特定大脑区域的作用，例如参与者犯错的试验中的背侧前扣带皮层，而其他研究则涉及人脑中许多分布更广泛的区域。先前的工作提出存在多个认知控制网络，从而提出了是否可以在每个网络中找到与错误相关的活动的问题。因此，为了广泛检查与错误相关的活动，我们进行了一项由 12 项任务组成的荟萃分析，其中包括错误试验和正确试验。这些任务因刺激输入（视觉、听觉）、响应输出（按钮按下、语音）、刺激类别（单词、图片）和任务类型（例如，识别记忆、心理旋转）而异。我们确定了 41 个大脑区域，这些区域对大多数任务中的错误和正确试验表现出不同的 fMRI BOLD 反应。这些区域显示出三种独特的反应概况：（1）快速，（2）延长，（3）对错误的延迟反应，以及对正确试验的更规范的反应。这些区域主要存在于几个控制网络中，每个网络主要显示一种响应配置文件。这种“一个网络，一种反应概况”观察的一个例外是额顶叶网络，它显示出长时间的反应概况（全部在右半球）和快速的反应概况（除了一个在左半球）。我们认为，这些发现指出了跨多个系统的一组大规模的错误相关区域，这些区域可能服务于不同的功能，而不是单一的局部错误机制。
A number of studies have focused on the role of specific brain regions, such as the dorsal anterior cingulate cortex during trials on which participants make errors, whereas others have implicated a host of more widely distributed regions in the human brain. Previous work has proposed that there are multiple cognitive control networks, raising the question of whether error-related activity can be found in each of these networks. Thus, to examine error-related activity broadly, we conducted a meta-analysis consisting of 12 tasks that included both error and correct trials. These tasks varied by stimulus input (visual, auditory), response output (button press, speech), stimulus category (words, pictures), and task type (e. g., recognition memory, mental rotation). We identified 41 brain regions that showed a differential fMRI BOLD response to error and correct trials across a majority of tasks. These regions displayed three unique response profiles: (1) fast, (2) prolonged, and (3) a delayed response to errors, as well as a more canonical response to correct trials. These regions were found mostly in several control networks, each network predominantly displaying one response profile. The one exception to this "one network, one response profile" observation is the frontoparietal network, which showed prolonged response profiles (all in the right hemisphere), and fast profiles (all but one in the left hemisphere). We suggest that, in the place of a single localized error mechanism, these findings point to a large-scale set of error-related regions across multiple systems that likely subserve different functions.