Effect of electron radiation on vasomotor function of the left anterior descending coronary artery.
Effect of electron radiation on vasomotor function of the left anterior descending coronary artery.
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DOI：
10.1016/j.lssr.2014.11.002
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发表时间：
2015-01
影响因子：
2.5
通讯作者：
Kennedy, Ann R
中科院分区：
文献类型：
--
作者：
Sanzari, Jenine K;Billings, Paul C;Wilson, Jolaine M;Diffenderfer, Eric S;Arce-Esquivel, Arturo A;Thorne, Pamela K;Laughlin, Maurice H;Kennedy, Ann R
左冠状动脉前降支（LAD，室间）为心脏中部区域提供血液供应，是血管狭窄的主要部位。 LAD 功能的变化会对心脏功能产生重大影响。在本报告中，我们研究了电子模拟太阳粒子事件 (eSPE) 辐射对猪动物模型中 LAD 功能的影响。评估了对二磷酸腺苷（ADP；10−9 – 10−4 M）、缓激肽（BK；10−11 – 10−6 M）和硝普钠（SNP；10−10 – 10−4 M）的血管舒张反应。分离对照（未照射）和 eSPE（照射）动物的 LAD 动脉，并在用 ADP 或 SNP 治疗后表现出类似的松弛反应。相反，与对照组相比，在 eSPE 照射组中观察到对 BK 治疗的松弛反应显着降低。这些数据表明，模拟 SPE 辐射暴露会改变 LAD 功能。
The left anterior descending (LAD, interventricular) coronary artery provides the blood supply to the mid-region of the heart and is a major site of vessel stenosis. Changes in LAD function can have major effects on heart function. In this report, we examined the effect of electron simulated solar particle event (eSPE) radiation on LAD function in a porcine animal model. Vasodilatory responses to adenosine diphosphate (ADP; 10−9 – 10−4 M), bradykinin (BK; 10−11 – 10−6 M), and sodium nitroprusside (SNP; 10−10 – 10−4 M) were assessed. The LAD arteries from Control (non-irradiated) and the eSPE (irradiated) animals were isolated and exhibited a similar relaxation response following treatment with either ADP or SNP. In contrast, a significantly reduced relaxation response to BK treatment was observed in the eSPE irradiated group, compared to the control group. These data demonstrate that simulated SPE radiation exposure alters LAD function.