Molecular imaging of the kidneys.
Molecular imaging of the kidneys.
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DOI：
10.1053/j.semnuclmed.2010.09.003
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发表时间：
2011-01
影响因子：
4.9
通讯作者：
Rabb H
中科院分区：
文献类型：
--
作者：
Szabo Z;Alachkar N;Xia J;Mathews WB;Rabb H
Radionuclide imaging of the kidneys with gamma cameras involves the use of labeled molecules seeking functionally critical molecular mechanisms in order to detect the pathophysiology of the diseased kidneys and achieve an early, sensitive and accurate diagnosis. The most recent imaging technology, PET, permits quantitative imaging of the kidney at a spatial resolution appropriate for the organ. H215O, 82RbCl, and [64Cu] ETS are the most important radiopharmaceuticals for measuring renal blood flow. The renin angiotensin system is the most important regulator of renal blood flow; this role is being interrogated by detecting angiotensin receptor subtype AT1R using in vivo PET imaging. Membrane organic anion transporters are important for the function of the tubular epithelium; therefore, Tc-99m MAG3 as well as some novel radiopharmaceuticals such as copper-64 labeled mono oxo-tetraazamacrocyclic ligands have been utilized for molecular renal imaging. Additionally, other radioligands that interact with the organic cation transporters or peptide transporters have developed. Focusing on early detection of kidney injury at the molecular level is an evolving field of great significance. Potential imaging targets are the kidney injury molecule- 1 (KIM-1) that is highly expressed in kidney injury and renal cancer but not in normal kidneys. While pelvic clearance, in addition to parenchymal transport, is an important measure in obstructive nephropathy, techniques that focus on upregulated molecules in response to tissue stress resulted from obstruction will be of great implication. Monocyte chemoattractant protein -1 (MCP-1) is a well-suited molecule in this case. The greatest advances in molecular imaging of the kidneys have been recently achieved in detecting renal cancer. In addition to the ubiquitous [18F]FDG, other radioligands such as [11C]acetate and anti-[18F]FACBC have emerged. Radioimmuno-imaging with [124I]G250 could lead to radioimmunotherapy for renal cancer. Considering the increasing age of general population, the incidence of kidney diseases such as atherosclerosis, diabetic nephropathy, and cancer is expected to increase. Successful management of these diseases offers an opportunity and a challenge for development of novel molecular imaging technologies.
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DOI：
10.1152/ajprenal.90762.2008
发表时间：
2009-12-01
影响因子：
4.2
作者：
Bouley, Richard;Palomino, Zaira;Jung, Flavia F.
通讯作者：
Jung, Flavia F.
DOI：
10.3736/jcim20080520
发表时间：
2008-05-01
期刊：
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
影响因子：
--
作者：
Ichimura, Takaharu;Mou, Shan
通讯作者：
Mou, Shan
影响因子：
4.5
作者：
Lawrentschuk, N;Poon, AMT;Scott, AM
通讯作者：
Scott, AM
影响因子：
51.1
作者：
Divgi, Chaitanya R.;Pandit-Taskar, Neeta;Russo, Paul
通讯作者：
Russo, Paul
影响因子：
8
作者：
Holmes, N;Harrison, MR;Baskin, LS
通讯作者：
Baskin, LS