Serum cystatin C levels are associated with coronary artery disease and its severity
Serum cystatin C levels are associated with coronary artery disease and its severity
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DOI：
10.1016/j.clinbiochem.2014.07.013
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发表时间：
2014-11-01
影响因子：
2.8
通讯作者：
Zhang, Jin-song
中科院分区：
文献类型：
--
作者：
Wang, Gan-nan;Sun, Kai;Zhang, Jin-song
目的：血清胱抑素C已被确定为心血管事件的预测因子。本研究的目的是评估胱抑素C在确定冠状动脉疾病（CAD）患者的存在和严重程度中的作用。设计和方法：本横断面研究共纳入936名无明显肾脏疾病的受试者。其中冠心病714例，无冠状动脉造影222例。根据胱抑素C四分位数将受试者进一步分为四组。采用颗粒增强免疫分析法测定血清胱抑素C。本研究分析了胱抑素C水平与冠心病存在及严重程度的关系，包括累及的狭窄血管数量和Gensini评分。结果：冠心病患者血清胱抑素C水平显著高于无冠心病患者（P < 0.001），且随冠脉累及程度的增加而显著升高（P < 0.001）。在胱抑素C最高的四分位数中，CAD的患病率及其严重程度也显著高于Gensini评分（P < 0.001）。在多元logistic回归模型中，胱抑素C水平与CAD的存在独立相关（P = 0.023），在线性回归分析中，胱抑素C水平与Gensini评分呈正相关（标准化β = 0.083, P = 0.010）。结论：在肾功能正常的患者中，血清胱抑素C水平升高与冠心病的存在和严重程度显著相关。提示胱抑素C可能在CAD诊断中发挥作用，并可作为CAD严重程度的标志。(C) 2014加拿大临床化学学会。Elsevier Inc.出版。版权所有。
Objectives: Serum cystatin C has been established as a predictor of cardiovascular events. The aim of this study was to evaluate the role of cystatin C in determining the presence and the severity of patients with coronary artery disease (CAD).Design and methods: A total of 936 subjects without overt renal disease were included in this cross-sectional study. Among them were 714 patients with CAD and 222 without based on coronary angiography. Subjects were further divided into four groups according to cystatin C quartile. Serum cystatin C was measured using particle-enhanced immunoassay method. The study analyzed the relationship of cystatin C levels with the presence and severity of CAD, including the number of stenotic vessels involved and Gensini score.Results: Serum cystatin C levels were significantly higher in patients with CAD than those without (P < 0.001), and significantly increased as the involvement of coronary vessels increased (P < 0.001). The prevalence of CAD and its severity assessed by Gensini score were also significantly greater in the highest quartile of cystatin C (P < 0.001). Moreover, cystatin C levels were independently correlated with the presence of CAD in a multivariate logistic regression model (P = 0.023) and were positively correlated with Gensini score by linear regression analysis (standardized beta = 0.083, P = 0.010).Conclusions: Elevated serum cystatin C levels were significantly associated with the presence and severity of CAD in patients with normal renal function. It is suggested that cystatin C might play a role in CAD diagnosis and serve as a marker of CAD severity. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.