Differences in Baseline Dark and the Dark-to-Light Changes in Anterior Chamber Angle Parameters in Whites and Ethnic Chinese
Differences in Baseline Dark and the Dark-to-Light Changes in Anterior Chamber Angle Parameters in Whites and Ethnic Chinese
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DOI：
10.1167/iovs.11-8470
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发表时间：
2011-12-01
影响因子：
4.4
通讯作者：
Lin, Shan
中科院分区：
文献类型：
--
作者：
Wang, Dandan;Chiu, Cynthia;Lin, Shan
目的.目的探讨40岁及以上中国人与白种人在黑暗条件下前房引流角宽度及暗-明变化（Delta）的差异。研究组包括四个年龄和性别匹配的队列：美国白人，美国华人，南方大陆华人和北方大陆华人。在光照和黑暗条件下获得前房角的眼前节光学相干断层扫描（ASOCT）图像。分析的参数包括房角开放距离（AOD）、房角凹陷面积（ARA）和小梁虹膜间隙面积（TISA）。数据分别来自121名、124名、121名和120名参与者，他们分别是美国白人、美国华人以及中国南方和北方大陆人。在多元线性回归分析中，校正了年龄、性别、屈光状态、瞳孔大小、透镜位置、前房深度（ACD）和前房宽度（ACW），中国人的ARA显著较小（回归系数，β =-0.06，P < 0.001）和TISA（β =-0.01，P = 0.039），以及比高加索人更大的Δ AOD（β = 0.03，P = 0.009）和Δ TISA（β = 0.02，P = 0.029）。对于暗-亮变化分析，仅在中国人中确定了虹膜角宽度与虹膜厚度（IT）和虹膜曲率（ICurv）之间的独立关联。与白种人相比，中国人的ARA和TISA较小，但AOD和TISA的明暗变化较大，与屈光状态和整体眼前段尺寸无关。（Invest Ophthalmol维斯科学。2011; 52：9404-9410）DOI：10.1167/iovs.11-8470
PURPOSE. To assess the anterior chamber drainage angle width in the dark and the dark-to-light change (Delta) between Caucasians and Chinese aged 40 years and older.METHODS. The study groups comprised four age-and sexmatched cohorts: American Caucasians, American Chinese, southern mainland Chinese, and northern mainland Chinese. Anterior segment optical coherence tomography (ASOCT) images of the anterior chamber angles were obtained under both light and dark conditions. The parameters analyzed included angle opening distance (AOD), angle recess area (ARA), and trabecular-iris space area (TISA).RESULTS. Data were obtained from 121, 124, 121, and 120 participants who were American Caucasians, American Chinese, and southern and northern mainland Chinese, respectively. In a multiple linear regression analysis, adjusted for age, sex, refractive status, pupil size, lens location, and anterior chamber depth (ACD) and width (ACW), the ethnic Chinese had significantly smaller ARAs (regression coefficient, beta = -0.06, P < 0.001) and TISAs (beta = -0.01, P = 0.039), as well as greater Delta AODs (beta = 0.03, P = 0.009) and Delta TISAs (beta = 0.02, P = 0.029) than did the Caucasians. For the dark-to-light change analysis, the independent associations between angle width and iris thickness (IT) and iris curvature (ICurv) were identified only in the Chinese.CONCLUSIONS. Compared with the Caucasians, the ethnic Chinese had smaller ARA and TISA, but greater dark-to-light changes in AOD and TISA, independent of refractive status and overall ocular anterior segment dimensions. (Invest Ophthalmol Vis Sci. 2011; 52: 9404-9410) DOI: 10.1167/iovs.11-8470