Male pattern baldness in relation to prostate cancer risks: an analysis in the VITamins and lifestyle (VITAL) cohort study.
Male pattern baldness in relation to prostate cancer risks: an analysis in the VITamins and lifestyle (VITAL) cohort study.
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男性型秃发与前列腺癌风险的关系：维生素和生活方式 (VITAL) 队列研究的分析。
DOI：
10.1002/pros.22927
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Cook,MichaelB
中科院分区：
文献类型：
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作者：
Zhou,CindyKe;Littman,AlysonJ;Levine,PaulH;Hoffman,HeatherJ;Cleary,SeanD;White,Emily;Cook,MichaelB
背景男性型秃发和前列腺癌在年龄增长、遗传性和内源性激素方面可能具有共同的病理生理机制。以前的流行病学研究结果不一致。因此，我们在维生素与生活方式 (VITAL) 队列研究中调查了 30 岁、45 岁和基线（中位年龄 = 60.5 岁）前列腺癌风险与男性型秃发的关联。 方法我们纳入了 32,583 名年龄在 50-76 岁且在随访开始时未曾诊断出癌症（不包括非黑色素瘤皮肤癌）的男性。通过与华盛顿西部监测、流行病学和最终结果 (SEER) 计划的联系，确定了首例原发性前列腺癌。使用 Cox 比例风险回归估计风险比 (HR) 和 95% 置信区间 (95% CI)，并调整潜在的混杂因素。 结果在随访期间（中位数 = 9 年），诊断出 2,306 例前列腺癌。 30 岁、45 岁和基线时的男性型秃发与前列腺癌的整体或亚型没有统计学显着相关性。结论这项研究没有为男性型秃发可能是后续前列腺癌的标志这一假设提供支持。先前的证据表明，额叶秃顶的不同类别可能与侵袭性前列腺癌的风险增加相关，但 VITAL 队列问卷将所有此类秃顶类别捕获为单一暴露类别。前列腺 75:415–423, 2015。 © 2014 Wiley periodicals, Inc.
BACKGROUNDMale pattern baldness and prostate cancer may share common pathophysiological mechanisms in terms of advancing age, heritability, and endogenous hormones. Results from previous epidemiologic studies are inconsistent. Therefore, we investigated the association of prostate cancer risks with male pattern baldness at age 30 years, age 45 years, and baseline (median age = 60.5 years) in the VITamins And Lifestyle (VITAL) cohort study.METHODSWe included 32,583 men who were aged 50–76 years and without prior cancer diagnosis (excluding non‐melanoma skin cancer) at the start of follow‐up. First primary incident prostate cancers were ascertained via linkage to the western Washington Surveillance, Epidemiology, and End Results (SEER) program. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards regressions with adjustment for potential confounders.RESULTSDuring follow‐up (median = 9 years), 2,306 incident prostate cancers were diagnosed. Male pattern baldness at age 30 years, age 45 years, and baseline were not statistically significantly associated with overall or subtypes of prostate cancer.CONCLUSIONThis study did not provide support for the hypothesis that male pattern baldness may be a marker for subsequent prostate cancer. Previous evidence indicates that a distinct class of frontal with vertex balding may be associated with increased risk of aggressive prostate cancer, but all such balding classes were captured as a single exposure category by the VITAL cohort questionnaire.Prostate 75:415–423, 2015. © 2014 Wiley Periodicals, Inc.