SEPARATION OF DIFFUSION AND PERFUSION IN INTRAVOXEL INCOHERENT MOTION MR IMAGING
SEPARATION OF DIFFUSION AND PERFUSION IN INTRAVOXEL INCOHERENT MOTION MR IMAGING
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DOI：
10.1148/radiology.168.2.3393671
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发表时间：
1988-08-01
期刊：
影响因子：
19.7
通讯作者：
LAVALJEANTET, M
中科院分区：
文献类型：
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作者：
LEBIHAN, D;BRETON, E;LAVALJEANTET, M
体素内非相干运动（IVIM）成像是作者开发的一种可视化水的微观运动的方法。在生物组织中，这些运动包括分子扩散和毛细血管网络中的血液微循环。IVIM图像通过表观扩散系数（ADC）量化，该系数综合了扩散和灌注的影响。这项工作的目的是证明灌注对ADC的贡献，并提出了一种获得扩散和灌注单独图像的方法。图像在0.5 T下使用高分辨率多切片序列获得，不使用造影剂。树脂微球模型的结果表明，该方法能够分别评估扩散和灌注。将该方法应用于脑、骨肿瘤和脑缺血患者。临床结果显示，该方法在通过灌注模式进行组织表征以及在生理和病理条件下评估微循环的功能研究（例如脑缺血）方面具有重要的前景。
Intravoxel incoherent motion (IVIM) imaging is a method the authors developed to visualize microscopic motions of water. In biologic tissues, these motions include molecular diffusion and microcirculation of blood in the capillary network. IVIM images are quantified by an apparent diffusion coefficient (ADC), which integrates the effects of both diffusion and perfusion. The aim of this work was to demonstrate how much perfusion contributes to the ADC and to present a method for obtaining separate images of diffusion and perfusion. Images were obtained at 0.5 T with high-resolution multisection sequences and without the use of contrast material. Results in a phantom made of resin microspheres demonstrated the ability of the method to separately evaluate diffusion and perfusion. The method was then applied in patients with brain and bone tumors and brain ischemia. Clinical results showed significant promise of the method for tissue characterization by perfusion patterns and for functional studies in the evaluation of the microcirculation in physiologic and pathologic conditions, as, for instance, in brain ischemia.