Increased cures using fractionated exposures of X irradiation and hyperthermia in the local treatment of the Ridgway osteogenic sarcoma in mice.
Increased cures using fractionated exposures of X irradiation and hyperthermia in the local treatment of the Ridgway osteogenic sarcoma in mice.
复制标题
在小鼠 Ridgway 成骨肉瘤的局部治疗中，使用分段 X 射线照射和热疗可提高治愈率。
作者：
E. W. Hahn;A. Alfieri;Jae Ho Kim
进行实验以确定热和/或 X 射线对 AKD2F1/J 雄性小鼠的里奇韦成骨肉瘤的影响。将平均直径为 0.9 ± 0.2 cm 的肿瘤每隔一天暴露于 200 rad 和/或热量下 3 次。在 x 照射之前或之后，将肿瘤核心温度维持在 42.5 ± 0.5 °C 15、30 或 45 分钟。单独加热并不能治愈，而单独辐射治愈了 18 只动物中的 8 只（44%）。相比之下，接受联合治疗的 74 只动物中有 71 只（96%）被治愈。无论是在肿瘤热疗之前还是之后立即进行放射治疗，其效果均相同。 15 分钟、30 分钟或 45 分钟热/辐射组的治愈率没有差异。
Experiments were carried out to determine the effect of heat and/or x rays on the Ridgway osteogenic sarcoma in AKD2F1/J male mice. Tumors averaging 0.9 ± 0.2 cm in diameter were exposed to 200 rads and/or heat three times on alternate days. Tumor core temperatures of 42.5 ± 0.5 °C were maintained for 15, 30 or 45 minutes immediately before or after x irradiation. Heat alone did not effect cures whereas radiation alone cured 8 of 18 animals (44%). In contrast, 71 of the 74 animals (96%) receiving the combined treatment were cured. Radiation was equally effective whether given immediately before or after tumor hyperthermia. There were no differences in cure rates in the 15-, 30- or 45-minute heat/radiation groups.