ANTITUMOR AGENTS .136. CUMINGIANOSIDES A-F, POTENT ANTILEUKEMIC NEW TRITERPENE GLUCOSIDES, AND CUMINDYSOSIDE-A AND CUMINDYSOSIDE-B, TRISNORTRITERPENE AND TETRANORTRITERPENE GLUCOSIDES WITH A 14,18-CYCLOAPOEUPHANE-TYPE SKELETON FROM DYSOXYLUM-CUMINGIANUM
ANTITUMOR AGENTS .136. CUMINGIANOSIDES A-F, POTENT ANTILEUKEMIC NEW TRITERPENE GLUCOSIDES, AND CUMINDYSOSIDE-A AND CUMINDYSOSIDE-B, TRISNORTRITERPENE AND TETRANORTRITERPENE GLUCOSIDES WITH A 14,18-CYCLOAPOEUPHANE-TYPE SKELETON FROM DYSOXYLUM-CUMINGIANUM
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DOI：
10.1021/jo00051a050
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发表时间：
1992-12-04
影响因子：
3.6
通讯作者：
LEE, KH
中科院分区：
文献类型：
--
作者：
KASHIWADA, Y;FUJIOKA, T;LEE, KH
从异木中分离出六个新的三萜苷类化合物：异木姜子苷A-F（1-6）和一个三降和四降三萜苷类化合物：异木姜子苷A（7）和B（8），它们具有14，18-环阿朴烷型骨架，是抗白血病的有效成分。这些结构是根据化学和光谱学证据确定的。其中，化合物1和3对MOLT-4人白血病细胞显示出强的选择性细胞毒性，其ED 50为
Six new triterpene glucosides, cumingianosides A-F (1-6) as well as a trisnor- and a tetranortriterpene glucoside, cumindysosides A (7) and B (8), respectively, with a 14,18-cycloapoeuphane-type skeleton have been isolated from Dysoxylum cumingianum as antileukemic principles. The structures were established on the basis of chemical and spectroscopic evidence. Among them, compounds 1 and 3 exhibited potent selective cytotoxicity against MOLT-4 human leukemia cell with ED50 of