Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics
Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics
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DOI：
10.1002/jbm.a.30260
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发表时间：
2005-04-01
影响因子：
4.9
通讯作者：
Kidoaki, S
中科院分区：
文献类型：
--
作者：
Matsuda, T;Ihara, M;Kidoaki, S
用合成的耐久弹性体--嵌段聚氨基甲酸酯，在高速横向运动的情况下，在芯棒上进行静电纺丝，制作了非织造网状小直径人工骨“机械活性”管状支架。重点讨论了芯棒的旋转速度和纤维在接触点的熔化或焊接状态如何影响由纵向和周向单轴拉伸确定的柔度(腔内压力依赖的周向膨胀)和杨氏模量。结果表明，高转速在整个应变范围内表现出各向同性的力学性能，但降低了柔度；使用高含量高沸点溶剂的混合溶剂产生的高熔融状态，降低了柔度，但在动脉循环系统中连续加载的脉动应力场中有望表现出高的耐久性。(C)2005年威利期刊公司。
To fabricate a "mechano-active" tubular scaffold of nonwoven mesh-type small-diameter artificial graft made of the synthetic durable elastomer, segmented polyurethane, the fabrication technique of electrospinning on a mandrel under a high rotation speed and transverse movement was used. Emphasis was placed on how the rotation speed of the mandrel and the fusion or welding states of fibers at contact points affect the compliance (ease of intraluminal pressure-dependent circumferential inflation) and Young's modulus determined by uniaxial stretching in the longitudinal and circumferential directions. The results showed that a high rotation speed is attributed to exhibit isotropic mechanical properties in the entire range of applied strain but reduces the compliance, and a high fusion state, which is produced using a mixed solvent with a high content of high-boiling-point solvent, reduces the compliance but is expected to exhibit high durability in a continuously loaded pulsatile stress field in an arterial circulatory system. (c) 2005 Wiley Periodicals, Inc.