Spatial Rule Learning and Corresponding CA1 Place Cell Reorientation Depend on Local Dopamine Release
Spatial Rule Learning and Corresponding CA1 Place Cell Reorientation Depend on Local Dopamine Release
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DOI：
10.1016/j.cub.2018.01.081
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发表时间：
2018-03-19
期刊：
影响因子：
9.2
通讯作者：
Morris, Genela
中科院分区：
文献类型：
--
作者：
Retailleau, Aude;Morris, Genela
激励驱动目标导向的行为；然而，它们如何影响目标相关海马图的形成和稳定仍然未知。由于多巴胺参与奖励处理，影响海马依赖行为，并调节海马可塑性，我们假设海马的局部多巴胺能传递有助于塑造海马认知图的形成和更新，以自适应地代表感觉输入的奖励预测空间。我们记录了大鼠的CA1位置细胞在空间额外维度设置移位任务的整个训练过程。在学会依赖两组正交信号中的一组后，我们引入了规则转移并局部注入了D1/5受体（D1/5R）拮抗剂SCH23390。成功的学习伴随着位置细胞的重新定位来表示与规则相关的空间维度。注射SCH23390阻止了这种重新定位，因此，学习受损，导致持久性。这些发现表明，多巴胺能神经支配向海马体提供奖励信息，对目标相关海马体表征的稳定至关重要，有助于成功的目标导向行为。
Incentives drive goal-directed behavior; however, how they impact the formation and stabilization of goal-relevant hippocampal maps remains unknown. Since dopamine is involved in reward processing, affects hippocampal-dependent behavior, and modulates hippocampal plasticity, we hypothesized that local dopaminergic transmission in the hippocampus serves to mold the formation and updating of hippocampal cognitive maps to adaptively represent reward-predicting space of sensory inputs. We recorded CA1 place cells of rats throughout training on a spatial extra-dimensional set-shift task. After learning to rely on one of two orthogonal sets of cues, we introduced a rule shift and infused locally the D1/5 receptor (D1/5R) antagonist SCH23390. Successful learning was accompanied by place cell reorientation to represent rule-relevant spatial dimension. SCH23390 infusion prevented this re-mapping and, consequently, impaired learning, causing perseveration. These findings suggest that dopaminergic innervation provides reward information to the hippocampus and is critical for the stabilization of goal-related hippocampal representation, contributing to successful goal-directed behavior.