Review Article SARS-CoV-2 host diversity: An update of natural infections and experimental evidence
Review Article SARS-CoV-2 host diversity: An update of natural infections and experimental evidence
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DOI：
10.1016/j.jmii.2020.06.006
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发表时间：
2021-04-22
影响因子：
7.4
通讯作者：
Saha, Sukumar
中科院分区：
文献类型：
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作者：
Hossain, Md Golzar;Javed, Aneela;Saha, Sukumar
由严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的冠状病毒病19（COVID-19）现在是一种流行性威胁。这种病毒应该是通过人际传播的。细胞血管紧张素转换酶2（ACE 2）是SARS-CoV-2的受体，其在不同物种的动物如猪、雪貂、猫、猩猩、猴子和人类中是相同或相似的。此外，最近的一项研究预测，在SARS-CoV-2从蝙蝠进化到人类的过程中，狗可能是第二宿主。因此，存在通过家养宠物传播SARS-CoV-2的可能性。现在有许多关于狗、猫、老虎、狮子和水貂的SARS-CoV-2阳性病例的报道。实验数据表明，雪貂和猫对SARS-CoV-2高度易感，因为它们是通过接种病毒感染的，可以通过飞沫或空气传播途径直接或间接传播病毒。根据这些自然感染报告和实验数据，宠物是否是SARS冠状病毒传播给人类的原因，需要深入调查。表现出呼吸道感染临床症状的人类一直在接受COVID-19诊断测试，但许多感染者和少数被证实患有SARS-CoV-2的宠物仍然没有症状。本文就SARS冠状病毒2型在动物体内的自然感染病例及最新研究进展进行综述。本文将有助于思考SARS-CoV-2的传播、扩散和血清阳性率研究的需求，特别是在伴侣动物中。由爱思唯尔台湾有限公司出版。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is now a pandemic threat. This virus is supposed to be spread by human to human transmission. Cellular angiotensin-converting enzyme 2 (ACE2) is the receptor of SARS-CoV-2 which is identical or similar in different species of animals such as pigs, ferrets, cats, orangutans, monkeys, and humans. Moreover, a recent study predicted that dogs might be secondary hosts during the evolution of SARS-CoV-2 from bat to human. Therefore, there is a possibility of spreading SARS-CoV-2 through domestic pets. There are now many reports of SARS-CoV-2 positive cases in dogs, cats, tigers, lion, and minks. Experimental data showed ferrets and cats are highly susceptible to SARS-CoV-2 as infected by virus inoculation and can transmit the virus directly or indirectly by droplets or airborne routes. Based on these natural infection reports and experimental data, whether the pets are responsible for SARS-CoV-2 spread to humans; needs to be deeply investigated. Humans showing clinical symptoms of respiratory infections have been undergoing for the COVID-19 diagnostic test but many infected people and few pets confirmed with SARS-CoV-2 remained asymptomatic. In this review, we summarize the natural cases of SARS-CoV-2 in animals with the latest researches conducted in this field. This review will be helpful to think insights of SARS-CoV-2 transmissions, spread, and demand for seroprevalence studies, especially in companion ani-mals.Copyright (c) 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).