Spectrum-effect relationship between HPLC fingerprints and hypolipidemic effect of Curcuma aromatica
Spectrum-effect relationship between HPLC fingerprints and hypolipidemic effect of Curcuma aromatica
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DOI：
10.1002/bmc.4220
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发表时间：
2018-07-01
影响因子：
1.8
通讯作者：
Feng, Jie
中科院分区：
文献类型：
--
作者：
Liu, Meiqiong;Wu, Youjiao;Feng, Jie
姜黄为传统中药，主要分布于中国广西。本研究从广西不同产地采集了10批芳香茶。采用HPLC技术建立指纹图谱，考察芳香茶的质量稳定性。通过相似性分析、灰色关联分析和多元线性回归分析评价芳香茶HPLC指纹图谱与降血脂作用的谱效关系。结果表明，各批次香薰与对照指纹图谱的相似度均>0.880，表明10批香香质量稳定性良好。选取20个共有峰作为指纹图谱，评价芳香茶的品质和降血脂作用。谱效关系结果表明，指纹图谱中的10、18、13、15、17峰与降血脂作用密切相关。本研究成功建立了芳香茶的HPLC指纹图谱与降血脂作用的谱效关系，为芳香茶的质量控制和更有效的研究提供了方法。也可为利用指纹图谱优化中药组方、开发中药提供一种简单有效的新方法。
Curcuma aromatica is used as a traditional Chinese medicine, and it is mainly distributed in Guangxi, China. In this study, 10 batches of C. aromatica were collected from different origins in Guangxi. The fingerprints were established by HPLC technique to investigate the quality stability of C. aromatica. The spectrum-effect relationship between HPLC fingerprints and hypolipidemic effect of C. aromatica was assessed by similarity analysis, gray relational analysis and multiple linear regression analysis. From the results, the similarity values between each batch of C. aromatica and reference fingerprint were >0.880, indicating the good quality stability of the 10 batches of C. aromatica. Twenty common peaks were selected as the fingerprints to evaluate the quality and hypolipidemic effect of C. aromatica. The results of spectrum-effect relationship showed that peaks 10, 18, 13, 15 and 17 in the fingerprints were closely related to hypolipidemic effect. This study successfully established the spectrum-effect relationship between HPLC fingerprints and hypolipidemic effect of C. aromatica, which provided methods for quality control and more effectively studies on bioactive compounds of C. aromatica. It could also provide a new simple and effective method for utilizing the fingerprints to optimize the Chinese prescription and develop traditional Chinese medicine.