Effects of unilateral and bilateral pyramidotomy on a conditioned rapid precision grip in monkeys (Macaca fascicularis)
Effects of unilateral and bilateral pyramidotomy on a conditioned rapid precision grip in monkeys (Macaca fascicularis)
复制标题
单侧和双侧锥体切开术对猴子（猕猴）条件性快速精确握力的影响
DOI：
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发表时间：
2004
影响因子：
2
通讯作者：
M. Wiesendanger
中科院分区：
文献类型：
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作者：
M. Hepp;E. Trouche;M. Wiesendanger
本研究训练两只猕猴（Macaca fascicularis）在一个小的传感器上进行快速条件性指握。当性能稳定到最短可能的反应时间时，在一只猴的一侧横切锥体束，在另一只猴的双侧横切锥体束。术后1-3周恢复再训练。反应潜伏期以及肌电图潜伏期和求和时间进行了测量前和长达几个月后，tumblemidotomy.The数据表明，tumblemidotomy诱导了一个持久的减缓的性能的fingergrip。这一减缓主要是由于运动的执行延迟。然而，一个短暂的显着延迟的运动之前的EMG活动的发作表明，不仅执行，而且启动有助于增加的平均反应潜伏期。双侧正中神经切断术的猴的缺陷更严重，持续时间更长，尤其是肌电图活动的开始延迟。这些赤字的机制和快速运动中的作用的锥体束进行了讨论，特别是在考虑同侧锥体束的可能功能。
SummaryTwo monkeys (Macaca fascicularis) were trained to perform fast conditioned fingergrip on a small transducer. When performance was stabilized to the shortest possible reaction time, the pyramidal tract was transected on one side in one monkey, bilaterally in another. Retraining was resumed 1–3 weeks after surgery. Response latency as well as electromyographic latency and summation time were measured before and up to several months after pyramidotomy.The data show that pyramidotomy induced a long-lasting slowing in the performance of the fingergrip. This slowing was due mainly to a delay in the execution of the movement. However, a short-lasting significant delay of the onset of the EMG activity preceding the movement shows that not only the execution but also the initiation contributes to the increase of the mean response latency. The deficits were more severe and of longer duration in the monkey with bilateral pyramidotomy, especially the delay in the onset of the EMG activity. The mechanisms underlying these deficits and the role of the pyramidal tract in rapid movements are discussed, specifically in consideration of the possible function of the ipsilateral pyramidal tract.