Toxicological and pathophysiological roles of reactive oxygen and nitrogen species.
Toxicological and pathophysiological roles of reactive oxygen and nitrogen species.
复制标题
DOI：
10.1016/j.tox.2010.07.009
复制
发表时间：
2010-10-09
期刊：
影响因子：
4.5
通讯作者：
Robertson FM
中科院分区：
文献类型：
--
作者：
Roberts RA;Smith RA;Safe S;Szabo C;Tjalkens RB;Robertson FM
“毒理学和疾病中的氧化和硝化应激”是 2009 年 9 月 15 日在德累斯顿举行的 EUROTOX 会议上举行的研讨会的主题。在组织发病过程中以及对病毒或化学毒物的反应中产生的活性氧 (ROS) 和活性氮 (RNS)，诱导一系列复杂的下游适应性和修复事件，这些事件是由相关的氧化和硝化应激驱动的。正如所有发言者所强调的那样，ROS 和 RNS 可以促进与一系列疾病相关的多种生物反应，包括神经退行性/神经精神疾病和心血管疾病。肝脏和皮肤癌变过程中也涉及类似的途径。从机制上讲，活性氧和氮物种驱动持续的细胞增殖、细胞死亡（包括凋亡和坏死）、核和线粒体 DNA 突变的形成，以及在某些情况下刺激促血管生成环境。在这里，我们阐述了氧化和硝化应激在细胞死亡、炎症和疼痛中发挥的关键作用及其对毒理学和疾病发病机制的影响。从体外模型系统到体内动物模型系统和临床结果的 5 个不同角度提供了示例。
‘Oxidative and Nitrative Stress in Toxicology and Disease’ was the subject of a symposium held at the EUROTOX meeting in Dresden 15th September 2009. Reactive oxygen (ROS) and reactive nitrogen species (RNS) produced during tissue pathogenesis and in response to viral or chemical toxicants, induce a complex series of downstream adaptive and reparative events driven by the associated oxidative and nitrative stress. As highlighted by all the speakers, ROS and RNS can promote diverse biological responses associated with a spectrum of disorders including neurodegenerative/neuropsychiatric and cardiovascular diseases. Similar pathways are implicated during the process of liver and skin carcinogenesis. Mechanistically, reactive oxygen and nitrogen species drive sustained cell proliferation, cell death including both apoptosis and necrosis, formation of nuclear and mitochondrial DNA mutations, and in some cases stimulation of a pro-angiogenic environment. Here we illustrate the pivotal role played by oxidative and nitrative stress in cell death, inflammation and pain and its consequences for toxicology and disease pathogenesis. Examples are presented from 5 different perspectives ranging from in vitro model systems through to in vivo animal model systems and clinical outcomes.
登录
查看更多内容
影响因子：
29.4
作者：
Krohn N;Kapoor S;Enami Y;Follenzi A;Bandi S;Joseph B;Gupta S
通讯作者：
Gupta S
影响因子：
11
作者：
Lin BR;Yu CJ;Chen WC;Lee HS;Chang HM;Lee YC;Chien CT;Chen CF
通讯作者：
Chen CF
影响因子：
3.4
作者：
Cheung, Yuen-Ting;Lau, Way Kwok-Wai;Chang, Raymond Chuen-Chung
通讯作者：
Chang, Raymond Chuen-Chung
影响因子：
3.3
作者：
Hunot, S;Bernard, V;Hirsch, EC
通讯作者：
Hirsch, EC
影响因子：
16
作者：
Ghisletti, Serena;Huang, Wendy;Glass, Christopher K.
通讯作者：
Glass, Christopher K.