[Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia].
[Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia].
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[长期大剂量甲钴胺治疗少精症患者的有效性研究]。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
T. Kitano
中科院分区：
文献类型：
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作者：
H. Moriyama;K. Nakamura;N. Sanda;E. Fujiwara;S. Seko;A. Yamazaki;M. Mizutani;K. Sagami;T. Kitano
少精子症患者给予甲钴胺(CH3-B12)6 mg/d(A组，16例)或12 mg/d(B组，23例)治疗16周。A组和B组的血清或精液中维生素B12浓度无差异。CH3-B12似乎能非常有效地转运到精液中。然而，A组和B组的结果在这一参数上没有不同。A组有效率为37.5%，B组为39.1%。从这些结果可以得出结论，长期、大剂量的CH3-B12治疗对少精子症患者是有效的。由于两组的有效率没有差异，推荐剂量为每天6 mg。观察两组各1例的临床不良反应。B组仅1例出现与药物相关的实验室不良反应。
Methylcobalamin (CH3-B12) was administrated in a dose of 6 mg per day (group A, 16 cases) or 12 mg per day (group B, 23 cases) for 16 weeks to patients with oligozoospermia. There was no difference between group A and group B regarding vitamin B12 concentrations in the serum or seminal fluid. CH3-B12 appeared to be transported to seminal fluid very efficiently. However, results from group A and group B did not differ with respect to this parameter. The efficacy rate for group A was 37.5% and that for group B was 39.1%. From these results, it was concluded that a long-term, high dose treatment of CH3-B12 was useful for the treatment of patients with oligozoospermia. Since the efficacy rates were not different between the two groups, 6 mg per day would be the recommended dose. Clinical adverse reactions were observed in one patient in each group. Drug-related laboratory adverse reactions were observed in only one patient in group B.