A method to determine the available UV-C dose for the decontamination of filtering facepiece respirators
A method to determine the available UV-C dose for the decontamination of filtering facepiece respirators
复制标题
DOI：
10.1111/j.1365-2672.2010.04881.x
复制
发表时间：
2011-01-01
影响因子：
4
通讯作者：
Shaffer, R. E.
中科院分区：
文献类型：
--
作者：
Fisher, E. M.;Shaffer, R. E.
目的：开发一种方法来评估模型特定参数的紫外线-C（UV-C，254 nm）去污过滤面罩呼吸器（FFRs）。方法和结果：UV-C透射率量化的不同复合层的6个N95 FFR模型，并用于计算模型特定的α值，表面UV-C辐照度的百分比可用于内部过滤介质（IFM）。圆形试样，切除的FFR，暴露于含有MS2大肠杆菌噬菌体的雾化颗粒，并与IFM特定的UV-C剂量范围从38至4707 J m-2的治疗。暴露于最小IFM剂量1000 J m-2的模型证明了活MS2至少有3个对数减少（LR）。模型特定的暴露时间，以实现该IFM剂量范围从2到266分钟。结论：UV-C传输到并通过FFR材料。MS2的LR是模型特定IFM UV-C doses.Significance和影响的函数研究：过滤面罩呼吸器在传染病爆发期间需求量很大，可能导致供应短缺。已经讨论了在去污后重复使用一次性FFR作为一种可能的补救策略，但迄今为止缺乏支持性科学证据。此处描述的方法可用于评估特定FFR模型的UV-C去污成功的可能性。
Aims:To develop a method to assess model-specific parameters for ultraviolet-C (UV-C, 254 nm) decontamination of filtering facepiece respirators (FFRs).Methods and Results:UV-C transmittance was quantified for the distinct composite layers of six N95 FFR models and used to calculate model-specific alpha-values, the percentage of the surface UV-C irradiance available for the internal filtering medium (IFM). Circular coupons, excised from the FFRs, were exposed to aerosolized particles containing MS2 coliphage and treated with IFM-specific UV-C doses ranging from 38 to 4707 J m-2. Models exposed to a minimum IFM dose of 1000 J m-2 demonstrated at least a 3 log reduction (LR) in viable MS2. Model-specific exposure times to achieve this IFM dose ranged from 2 to 266 min.Conclusions:UV-C transmits into and through FFR materials. LR of MS2 was a function of model-specific IFM UV-C doses.Significance and Impact of the Study:Filtering facepiece respirators are in high demand during infectious disease outbreaks, potentially leading to supply shortages. Reuse of disposable FFRs after decontamination has been discussed as a possible remediation strategy, but to date lacks supporting scientific evidence. The methods described here can be used to assess the likelihood that UV-C decontamination will be successful for specific FFR models.