A Magnetically Guided Self-Rolled Microrobot for Targeted Drug Delivery, Real-Time X-Ray Imaging, and Microrobot Retrieval
A Magnetically Guided Self-Rolled Microrobot for Targeted Drug Delivery, Real-Time X-Ray Imaging, and Microrobot Retrieval
复制标题
用于靶向药物递送、实时x射线成像和微型机器人检索的磁引导自滚微型机器人
DOI：
10.1002/adhm.202001681
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发表时间：
2021-01-27
影响因子：
10
通讯作者：
Choi, Eunpyo
中科院分区：
文献类型：
--
作者：
Nguyen, Kim Tien;Go, Gwangjun;Choi, Eunpyo
使用微型机器人的靶向药物递送是一种有前途的技术，能够克服依赖于身体循环的传统化疗的局限性。然而，大多数用于药物输送的微型机器人的研究只证明了简单的移动性，而不是精确的靶向方法，并证明了药物输送后植入的微型机器人生物降解的可能性。在这项研究中，磁引导自滚动微型机器人，使自主导航为基础的靶向药物输送，实时X射线成像，和微型机器人检索提出。微型机器人由使用聚焦光打印的自滚动体和附着有磁性纳米颗粒的表面组成，展示了阿霉素和X射线造影剂的装载，用于癌症治疗和X射线成像。在实时X射线成像下，通过使用电磁致动系统的磁场控制的自动靶向，微型机器人被精确地移动到病变部位。使用近红外光的光热效应揭示了位于病变部位的微型机器人的快速药物释放。在药物输送后，微型机器人通过使用磁场可切换的线圈导管植入或降解而恢复，而没有潜在的毒性。这种微机器人的方法，使用自动控制方法的治疗剂加载的微机器人在精确的局部药物输送系统有潜在的用途。
Targeted drug delivery using a microrobot is a promising technique capable of overcoming the limitations of conventional chemotherapy that relies on body circulation. However, most studies of microrobots used for drug delivery have only demonstrated simple mobility rather than precise targeting methods and prove the possibility of biodegradation of implanted microrobots after drug delivery. In this study, magnetically guided self-rolled microrobot that enables autonomous navigation-based targeted drug delivery, real-time X-ray imaging, and microrobot retrieval is proposed. The microrobot, composed of a self-rolled body that is printed using focused light and a surface with magnetic nanoparticles attached, demonstrates the loading of doxorubicin and an X-ray contrast agent for cancer therapy and X-ray imaging. The microrobot is precisely mobilized to the lesion site through automated targeting using magnetic field control of an electromagnetic actuation system under real-time X-ray imaging. The photothermal effect using near-infrared light reveals rapid drug release of the microrobot located at the lesion site. After drug delivery, the microrobot is recovered without potential toxicity by implantation or degradation using a magnetic-field-switchable coiled catheter. This microrobotic approach using automated control method of the therapeutic agents-loaded microrobot has potential use in precise localized drug delivery systems.