Ectopic Neuroblastoma in Monozygotic Twins With Different Ages of Onset : Possible Twin-to-Twin Metastasis In Utero With Distinct Genetic Alterations After Birth
Ectopic Neuroblastoma in Monozygotic Twins With Different Ages of Onset : Possible Twin-to-Twin Metastasis In Utero With Distinct Genetic Alterations After Birth
复制标题
不同发病年龄的同卵双胞胎中的异位神经母细胞瘤：可能在子宫内发生双胞胎到双胞胎的转移，并在出生后出现明显的基因改变
DOI：
10.1097/mph.0b013e318290c686
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Yamaguchi S
中科院分区：
文献类型：
--
作者：
Taketani T;Takita J;Ueyama J;Kanai R;Kumori K;Maruyama R;Hayashi K;Ogawa S;Fukuda S;Yamaguchi S
我们描述了单卵双胞胎的神经母细胞瘤(NB)，其发病年龄间隔为3年。双生子1的原发肿瘤部位为肾上腺，而双生子2的肿瘤部位为空肠/肠系膜。不同原发肿瘤的MYCN扩增、DNA指数、ALK突变、DNA拷贝数改变均不同。异位部位的NB可能是通过胎盘血管吻合的双胞胎到双胞胎转移所致。该病的发病机制涉及胎儿发育过程中的癌前阶段和出生后随后的分子变化，导致表型相似但基因不同的NBs。
We describe neuroblastoma (NB) in monozygotic twins whose ages at the onset of the disease had a 3-year interval. The primary tumor site of twin 1 was the adrenal gland, whereas that of twin 2 was the jejunum/mesentery. MYCN amplification, DNA index, ALK mutation, and copy number alterations of DNA were different between each primary tumor. NB in ectopic sites may have resulted from twin-to-twin metastasis through vascular anastamoses in the placenta. The pathogenesis of this NB involved a premalignant stage of NB during the fetal development and subsequent molecular alterations after birth, resulting in NBs that were phenotypically similar but genetically different.