Paradoxical Increase in Rate of Catabolism of Low-Density Lipoproteins after Hepatectomy
Paradoxical Increase in Rate of Catabolism of Low-Density Lipoproteins after Hepatectomy
复制标题
肝切除术后低密度脂蛋白分解代谢率反常增加
作者：
A. Sniderman;T. Carew;James G. Chandler;D. Steinberg
It has been suggested that the liver may be a major site for irreversible degradation of low-density lipoprotein (LDL). The disappearance of autologous 125I-labeled LDL from plasma was compared in intact and in hepatectomized swine. Contrary to expectations, the rate of irreversible removal of LDL from plasma was increased rather then decreased by hepatectomy. These studies suggest that the liver is not a major site for LDL removal. We propose further that the liver (or some function requiring an intact liver) may affect the metabolism of LDL in a manner that prolongs its lifetime in the plasma compartment.
