Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings
Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings
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DOI：
10.1016/j.drugalcdep.2007.11.023
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发表时间：
2008-05-01
影响因子：
4.2
通讯作者：
Cottler, Linda B.
中科院分区：
文献类型：
--
作者：
Bierut, Laura Jean;Strickland, Jaime R.;Cottler, Linda B.
背景：本研究的目的是调查可卡因依赖者及其兄弟姐妹的物质使用和依赖，并与从同一社区招募的个人及其兄弟姐妹进行比较，以更好地了解家庭和邻居对依赖发展的贡献。以社区为基础的受试者在年龄、种族、性别和邮政编码上与可卡因依赖指数病例相匹配。结果：可卡因依赖者使用所有研究物质的可能性明显高于社区受试者，依赖酒精和其他非法药物的可能性是社区受试者的2-10倍。仅依赖可卡因的情况并不常见(
Background: The purpose of this study was to examine substance use and dependence among cocaine dependent subjects and their siblings compared to individuals recruited from the same neighborhood and their siblings in order to better understand family and neighborhood contributions to the development of dependence.Methods: Cocaine dependent subjects were recruited through treatment centers. Community-based subjects were matched to cocaine dependent index cases on age, ethnicity, gender, and zip code. One full sibling for each case and community-based subject participated.Results: Cocaine dependent subjects were significantly more likely than community-based subjects to use all substances studied and were 2-10 times more likely to be dependent on alcohol and other illicit drugs. Dependence only on cocaine was uncommon (