Integrative pan cancer analysis reveals the importance of CFTR in lung adenocarcinoma prognosis
Integrative pan cancer analysis reveals the importance of CFTR in lung adenocarcinoma prognosis
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综合泛癌分析揭示 CFTR 在肺腺癌预后中的重要性
DOI：
10.1016/j.ygeno.2022.110279
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发表时间：
2022-02-10
期刊：
影响因子：
4.4
通讯作者：
Cai，Kaican
中科院分区：
文献类型：
--
作者：
Shi，Xiaoshun;Kou，Mengying;Cai，Kaican
囊性纤维化（CF）和囊性纤维化跨膜传导调节因子（CFTR）突变已被证明与多种癌症的风险相关。然而，CFTR基因异常表达在人类肿瘤中的临床意义仍然未知。从PubMed、奥维德、CNKI、TCGA、ONCOMINE、PrognoScan和GEPIA数据库中确定了CFTR在人类癌症中的表达谱和预后情况。来自文献、GEPIA数据库和PrognoScan数据库的超过11，000个癌症样本被纳入本研究。总体而言，CFTR在癌症中的表达和预后情况各不相同，但交叉数据库和荟萃分析的结果显示CFTR是LUAD预后的可靠生物标志物。总的来说，本研究表明CFTR是LUAD生存的重要预后生物标志物，这意味着它可以用作LUAD的预后生物标志物和治疗靶点。
Cystic fibrosis (CF) and cystic fibrosis transmembrane conductance regulator (CFTR) mutations have been shown to be associated with the risk of a variety of cancers. However, the clinical significance of aberrantCFTRgene expression in human tumors remains unknown. The expression profiles and prognostic landscapes ofCFTRin human cancers were identified from the PubMed, OVID, CNKI, TCGA, ONCOMINE, PrognoScan, and GEPIA databases. Over 11, 000 cancer samples from the literature, GEPIA database, and PrognoScan database were included in this study. In general,CFTRhas various expression and prognostic profiles in cancers, but the results from cross-database and meta-analyses revealed thatCFTRis a robust biomarker for LUAD prognosis. Collectively, this study suggests thatCFTRis an important prognostic biomarker for LUAD survival, implying that it could be used as a prognostic biomarker and therapeutic target for LUAD.