Mumps Postexposure Prophylaxis with a Third Dose of Measles-Mumps-Rubella Vaccine, Orange County, New York, USA
Mumps Postexposure Prophylaxis with a Third Dose of Measles-Mumps-Rubella Vaccine, Orange County, New York, USA
复制标题
使用第三剂麻疹-腮腺炎-风疹疫苗预防腮腺炎暴露后，美国纽约州奥兰治县
DOI：
--
复制
发表时间：
2013
影响因子：
11.8
通讯作者：
Gregory S. Wallace
中科院分区：
文献类型：
--
作者：
A. Fiebelkorn;J. Lawler;A. Curns;Christina Brandeburg;Gregory S. Wallace
尽管不推荐将麻疹-腮腺炎-风疹 (MMR) 疫苗用于腮腺炎暴露后预防 (PEP)，但有关其有效性的数据有限。 2009-2010 年美国东北部流行性腮腺炎爆发期间，我们在正统犹太家庭的接触者中评估了 PEP 接种第三剂 MMR 疫苗的有效性，这些接触者在家庭指标患者腮腺炎发病后 5 天内接种了第三剂。我们比较了在指标患者发病后第一个潜伏期内接受第三剂 MMR 疫苗的人和未接种 2 剂疫苗的人之间的腮腺炎发病率。 239 名符合资格的家庭成员中，有 28 名 (11.7%) 接受了第三次 MMR 剂量作为 PEP。第三剂接种者的腮腺炎发病率为 0%，而没有 PEP 的 2 剂接种者的腮腺炎发病率为 5.2%（p = 0.57）。尽管作为 PEP 施用的第三剂 MMR 剂量没有产生显着效果，但它可能在特定的疫情背景下提供一些好处。
Although the measles-mumps-rubella (MMR) vaccine is not recommended for mumps postexposure prophylaxis (PEP), data on its effectiveness are limited. During the 2009–2010 mumps outbreak in the northeastern United States, we assessed effectiveness of PEP with a third dose of MMR vaccine among contacts in Orthodox Jewish households who were given a third dose within 5 days of mumps onset in the household’s index patient. We compared mumps attack rates between persons who received a third MMR dose during the first incubation period after onset in the index patient and 2-dose vaccinated persons who had not. Twenty-eight (11.7%) of 239 eligible household members received a third MMR dose as PEP. Mumps attack rates were 0% among third-dose recipients versus 5.2% among 2-dose recipients without PEP (p = 0.57). Although a third MMR dose administered as PEP did not have a significant effect, it may offer some benefits in specific outbreak contexts.