Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study
Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study
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DOI：
10.1093/annonc/mdt105
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发表时间：
2013-07-01
影响因子：
50.5
通讯作者：
Wolk, A.
中科院分区：
文献类型：
--
作者：
Discacciati, A.;Orsini, N.;Wolk, A.
背景资料：关于咖啡消费与前列腺癌（PCa）风险之间可能关系的流行病学证据（按疾病亚型）（局部的、晚期的）和致命的PCa风险是有限的。从1998年1月至2010年12月，对44613名年龄在45-79岁之间的瑞典男性进行了基于人群的队列随访，以了解局部性（n = 2368）、晚期（n = 918）和致死性（n = 515）PCa。我们使用竞争风险回归评估了咖啡消费与局部，晚期和致命PCa风险之间的关联。结果：对于局部前列腺癌，每日咖啡摄入量每增加1杯，其风险降低3%[亚危害比（SHR）= 0.97，95%可信区间（CI）= 0.95-0.99]。对于晚期和致死性PCa，我们发现了非显著的负相关性;每增加一个杯与晚期[SHR（95% CI）= 0.98（0.95-1.02）]和致死性PCa [SHR（95% CI）= 0.98（0.93-1.03）]风险降低2%相关。我们观察到BMI对局部PCa影响的证据（P-交互作用= 0.03）;与正常体重男性（BMI < 25 kg/m2）相比，超重和肥胖男性（BMI >= 25 kg/m2）的负相关性更强。结论：我们观察到咖啡摄入量与局部PCa风险之间存在明显的负相关性，尤其是在超重和肥胖男性中。
Background: The epidemiological evidence on possible relationships between coffee consumption and prostate cancer (PCa) risk by subtype of the disease (localized, advanced) and fatal PCa risk is limited.Materials and methods: A population-based cohort of 44 613 Swedish men aged 45-79 years was followed up from January 1998 through December 2010 for incidence of localized (n = 2368), advanced (n = 918) and fatal (n = 515) PCa. We assessed the associations between coffee consumption and localized, advanced and fatal PCa risk using competing-risk regressions. We examined possible effect modification by body mass index (BMI).Results: For localized PCa, each one cup increase in daily coffee consumption was associated with a 3% reduced risk [sub-hazard ratio (SHR) = 0.97, 95% confidence interval (CI) = 0.95-0.99]. For advanced and fatal PCa, we found a non-significant inverse association; each one cup increase was associated with a 2% reduced risk of advanced [SHR (95% CI) = 0.98 (0.95-1.02)] and fatal PCa [SHR (95% CI) = 0.98 (0.93-1.03)]. We observed evidence of effect modification by BMI for localized PCa (P-interaction = 0.03); the inverse association was stronger among overweight and obese men (BMI >= 25 kg/m(2)) compared with normal-weight men (BMI < 25 kg/m(2)).Conclusions: We observed a clear inverse association between coffee consumption and risk of localized PCa, especially among overweight and obese men.