MALIGNANT MESOTHELIOMAS AND CHEMOTHERAPY
MALIGNANT MESOTHELIOMAS AND CHEMOTHERAPY
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DOI：
10.1002/jso.2930150209
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
MOORE, R
中科院分区：
文献类型：
--
作者：
KARAKOUSIS, CP;SEDDIQ, M;MOORE, R
在77例间皮瘤患者中，63.6%有胸膜受累，31.2%有腹膜受累，5.2%在其他部位受累。症状表现因原发部位不同而异。手术和放疗似乎并不影响弥漫型的病程。在接受全身化疗（环磷酰胺、阿霉素、长春新碱、甲氨蝶呤、5 - 氟尿嘧啶、达卡巴嗪）的41例患者中，3例完全缓解，4例客观缓解率大于50%（中位生存期42.5个月）；18例病情稳定（中位生存期12.8个月），16例无缓解（中位生存期4.5个月）。缓解者和未缓解者之间的生存期差异具有统计学意义（P < 0.001）。在接受二线化疗的16例患者中，4例完全缓解（中位生存期17.5个月），6例病情稳定（中位生存期10.5个月），6例无缓解（中位生存期2.5个月）。化疗在间皮瘤的治疗中似乎有一定效果。
Of 77 patients with mesotheliomas, 63.6% had pleural involvement, 31.2% had peritoneal involvement and 5.2% had involvement at other sites. The presenting symptoms varied with the location of the primary. Surgery and irradiation did not appear to influence the course of the diffuse type. Of 41 patients given systemic chemotherapy [cyclophosphamide, adriamycin, vincristine, methotrexate, 5-fluorouracil, dacarbazine], 3 had complete response and 4 had greater than 50% objective response (median survival 42.5 months); 18 patients had stabilization (median 12.8 mo.) and 16 showed no response (median 4.5 mo.). The difference in survival between responders and non-responders was statistically significant (P < 0.001). Of 16 patients who received secondary chemotherapy, 4 had complete response (median survival 17.5 mo.), 6 had stabilization (median 10.5 mo.) and 6 had no response (median 2.5 mo.). Chemotherapy appears moderately effective in the treatment of mesotheliomas.