METABOLIC RESPONSES DURING MYOCARDIAL REACTIVE HYPEREMIA IN THE UNANESTHETIZED DOG.
METABOLIC RESPONSES DURING MYOCARDIAL REACTIVE HYPEREMIA IN THE UNANESTHETIZED DOG.
复制标题
未麻醉狗心肌反应性充血期间的代谢反应。
DOI：
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发表时间：
1965
影响因子：
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通讯作者：
D. E. Gregg
中科院分区：
文献类型：
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作者：
R. Olsson;D. E. Gregg
对未麻醉犬反应性充血时心肌代谢的研究表明，反应性充血时A-V氧差持续降低。然而，由于冠状动脉血流速度的增加大于A-V氧差的减少，心肌氧消耗率增加。氧气债总是被过度支付，尽管这是一个很大的问题。A-V乳酸盐和丙酮酸盐差异的研究表明，超过6秒的闭塞通常会导致乳酸盐产生，而短于此的闭塞则不会。这表明，心肌反应性充血是一种代谢反应的代谢产物所产生的，即使是轻度缺氧。这种代谢物对冠状动脉血流量的影响似乎与缺氧刺激不成比例。
Studies of myocardial metabolism during reactive hyperemia in unanesthetized dogs reveals that A-V oxygen difference is consistently decreased during reactive hyperemia. Myocardial oxygen consumption rate is increased, however, as the increase in coronary blood flow rate is greater than the decrease in A-V oxygen difference. Oxygen debt is always, though variably, overpaid. Studies of A-V lactate and pyruvate differences show that occlusions of more than 6 sec regularly lead to lactate production, while occlusions shorter than this do not. It is suggested that myocardial reactive hyperemia is a metabolic response to a metabolite produced by even mild degrees of anoxia. The effects of this metabolite on coronary blood flow appear to be out of proportion to the anoxic stimulus.