LINKAGE MAP OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX INCLUDING THE TUMOR-NECROSIS-FACTOR GENES
LINKAGE MAP OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX INCLUDING THE TUMOR-NECROSIS-FACTOR GENES
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DOI：
10.1073/pnas.84.23.8535
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发表时间：
1987-12-01
影响因子：
11.1
通讯作者：
SPIES, T
中科院分区：
文献类型：
--
作者：
CARROLL, MC;KATZMAN, P;SPIES, T
肿瘤坏死因子（TNF）α。和β基因对在人类主要组织相容性复合体中通过脉冲场凝胶电泳与HLA-B、HLA-C以及暂时的HLA-E和HLA-A连接，并且与III类补体/类固醇21-羟化酶基因簇连接。TNF基因位于HLA-B的着丝粒200 kb和III类簇的端粒约350 kb处。连同先前关于II类和III类区域的连锁和结构的数据，已经制备了约3500 kb的整个人主要组织相容性复合体的限制性图谱。
The tumor necrosis factor (TNF) .alpha. and .beta. gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.