Amplification of the stereochemistry of biomolecular adsorbates by deracemization of chiral domains in bent-core liquid crystals.
Amplification of the stereochemistry of biomolecular adsorbates by deracemization of chiral domains in bent-core liquid crystals.
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DOI：
10.1002/adma.201203302
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发表时间：
2013-01-11
影响因子：
29.4
通讯作者：
Takezoe, Hideo
中科院分区：
文献类型：
--
作者：
Lee, Guksik;Carlton, Rebecca J.;Araoka, Fumito;Abbott, Nicholas L.;Takezoe, Hideo
手性是化学和生物学中的一个重要概念，在许多物质中都观察到手性不对称，如酒石酸盐[1]和生物螺旋，如DNA， RNA和多肽。液晶中的手性通常是由具有光学活性的手性分子引起的，例如，用手性分子掺杂非手性介原。这样的手性晶体通常形成螺旋状的上层结构，可以是一维的（胆甾相、手性近晶相和扭转晶界相），也可以是三维的（蓝色相）在本文中，我们将探讨使用lc来放大表面生物分子手性的一般但具有挑战性的想法。这项研究的动机是提出非手性或外消旋LCs，其中手性是由外部手性刺激（如手性表面）诱导的，从长远来看，[3]可能能够设计出新型的生物-非生物界面，其中生物分子的手性在LCs的组织中被报道。在这里，我们使用弯核液晶（bclc，也称为香蕉形液晶）来探索这一想法。[4,5]非手性BCLC体系的宏观光学活性在B2、[6]、bb4、[7]和暗砾岩（DC）相中被观察到B2相是分子从层法线倾斜的近晶相，因此手性由分子长轴的相对取向，即方向来定义
Chirality is a key concept found in both chemistry and biology, with chiral asymmetries observed in many substances such as tartrates [1] and biological helices, eg, DNA, RNA, and polypeptide. Chirality in liquid crystals (LCs) is commonly induced by the presence of optically active chiral molecules, for instance, by doping non-chiral mesogens with chiral molecules. Such chiral LCs typically form helical suprastructures,[2] which can be either one-dimensional (cholesteric, chiral smectic C, and twist grain boundary phases) or threedimensional (blue phases).[2] In this paper, we move to explore the general but challenging idea of using LCs to amplify biomolecular chirality at surfaces. The study was motivated by the proposal that achiral or racemic LCs, in which chirality is induced by external chiral stimuli such as a chiral surface,[3] might, in the long-term, enable the design of new classes of biotic-abiotic interfaces in which the chirality of biomolecules is reported in the organization of the LCs. Herein we explore this idea using bent-core LCs (BCLCs, also known as banana-shaped liquid crystals).[4, 5] Macroscopic optical activity in the non-chiral BCLC systems has been observed in the B2,[6] B4,[7] and dark conglomerate (DC) phases.[8] The B2 phase is a smectic phase with molecules tilted from the layer normal such that the chirality is defined by the relative orientation of the molecular long axis, the direction
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影响因子：
19
作者：
Sivakumar, Sri;Wark, Kim L.;Caruso, Frank
通讯作者：
Caruso, Frank
影响因子：
56.9
作者：
Hough, L. E.;Jung, H. T.;Clark, N. A.
通讯作者：
Clark, N. A.
影响因子：
3.9
作者：
Brake, JM;Daschner, MK;Abbott, NL
通讯作者：
Abbott, NL
弯核液晶 B4 相中螺旋丝的手性保持生长
影响因子：
15
作者：
Chen, Dong;Maclennan, Joseph E.;Clark, Noel A.
通讯作者：
Clark, Noel A.
影响因子：
3.4
作者：
Price, Andrew D.;Ignes-Mullol, Jordi;Schwartz, Daniel K.
通讯作者：
Schwartz, Daniel K.