Derivatized oxopiperazine rings from amino acids
Derivatized oxopiperazine rings from amino acids
复制标题
DOI：
10.1016/s0040-4039(97)00726-0
复制
发表时间：
1997-05-26
影响因子：
1.8
通讯作者：
Roberts, E
中科院分区：
文献类型：
--
作者：
Bhatt, U;Mohamed, N;Roberts, E
本文报道了两种合成衍生化氧哌嗪的途径，其可能作为约束肽模拟物。该合成采用还原胺化和磺胺化方法生成n -烯丙基氨基酸酯衍生物并利用它们组装环体系。用这种方法制备了阿斯巴甜类似物。1997爱思唯尔科学有限公司
Two routes for the synthesis of derivatized oxopiperazines, which may act as constrained peptide mimics, are reported. The syntheses employ reductive amination and sulfonamide approaches for generating N-allylic amino acid ester derivatives and utilizing them for assembling the ring systems. An aspartame analog was prepared using this methodology. (C) 1997 Elsevier Science Ltd.