Association of serum alanine aminotransferase and γ-glutamyltransferase levels within the reference range with metabolic syndrome and nonalcoholic fatty liver disease.
Association of serum alanine aminotransferase and γ-glutamyltransferase levels within the reference range with metabolic syndrome and nonalcoholic fatty liver disease.
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DOI：
10.3350/kjhep.2011.17.1.27
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Kim HC
中科院分区：
文献类型：
--
作者：
Oh HJ;Kim TH;Sohn YW;Kim YS;Oh YR;Cho EY;Shim SY;Shin SR;Han AL;Yoon SJ;Kim HC
非酒精性脂肪性肝病（NAFLD）是代谢综合征（MS）的一个新的组成部分，MS是慢性肝病的主要原因之一。提示血清谷丙转氨酶（ALT）和γ-谷氨酰转移酶（GGT）水平影响肝脏脂肪蓄积和胰岛素抵抗。我们评估了参考范围内的血清ALT和GGT浓度与MS和NAFLD的相关性。根据参考范围内的血清ALT和GGT浓度水平，将元光大学医院健康促进中心招募的1，069名受试者分为4组。我们进行了生化检查，包括肝功能检查和血脂检查，并通过超声诊断脂肪肝。研究了参考范围内的ALT和GGT浓度分级与脂肪肝和/或MS的关系。MS及其组分的存在和代谢异常[高密度脂蛋白胆固醇（HDL-C）和空腹血糖除外]的数量随ALT水平升高而增加，而MS及其组分的存在和代谢异常（HDL-C除外）的数量随GGT水平升高而增加。脂肪肝和MS的比值比随ALT水平（分别为P<0.001和P=0.049）和GGT水平（分别为P=0.044和P=0.039）而增加。参考范围内的血清ALT和GGT浓度与NAFLD和MS的发生率呈剂量依赖性相关。这些关联需要在大型前瞻性研究中得到证实。
Nonalcoholic fatty liver disease (NAFLD) has recently been found to be a novel component of metabolic syndrome (MS), which is one of the leading causes of chronic liver disease. The serum alanine aminotransferase (ALT) and γ-glutamyltransferase (GGT) levels are suggested to affect liver fat accumulation and insulin resistance. We assessed the associations of serum ALT and GGT concentrations within the reference ranges with MS and NAFLD. In total, 1,069 subjects enrolled at the health promotion center of Wonkwang University Hospital were divided into 4 groups according to serum ALT and GGT concentrations levels within the reference ranges. We performed biochemical tests, including liver function tests and lipid profiles, and diagnosed fatty liver by ultrasonography. Associations of ALT and GGT concentrationgrading within the reference range with fatty liver and/or MS were investigated. The presence of MS, its components, and the number of metabolic abnormalities [except for high-density lipoprotein-cholesterol (HDL-C) and fasting blood glucose] increased with the ALT level, while the presence of MS, its components, and the number of metabolic abnormalities (except for HDL-C) increased with the GGT level. The odds ratios for fatty liver and MS increased with the ALT level (P<0.001 and P=0.049, respectively) and the GGT level (P=0.044 and P=0.039, respectively). Serum ALT and GGT concentrations within the reference ranges correlated with the incidence of NAFLD and MS in a dose-dependent manner. There associations need to be confirmed in large, prospective studies.