Interspecies communication in bacteria.
Interspecies communication in bacteria.
复制标题
DOI：
10.1172/jci20195
复制
发表时间：
2003-11
期刊：
影响因子：
--
通讯作者：
Michael J. Federle;B. Bassler
中科院分区：
文献类型：
--
作者：
Michael J. Federle;B. Bassler
直到最近，人们还认为细菌过着不合群、隐居的生活。新的研究表明，事实上，细菌拥有复杂的化学信号系统，使它们能够在物种内部和物种之间进行交流。一种被称为AI-2的信号似乎是通用的，有助于物种间的交流。许多过程，包括毒力因子的产生、生物膜的形成和运动，都由AI-2控制。生物技术行业正在探索干扰细菌通讯的策略，目的是开发新的抗菌剂。AI-2是一个特别有吸引力的候选者，因为它在微生物领域的广泛应用。
Until recently, bacteria were considered to live rather asocial, reclusive lives. New research shows that, in fact, bacteria have elaborate chemical signaling systems that enable them to communicate within and between species. One signal, termed AI-2, appears to be universal and facilitates interspecies communication. Many processes, including virulence factor production, biofilm formation, and motility, are controlled by AI-2. Strategies that interfere with communication in bacteria are being explored in the biotechnology industry with the aim of developing novel antimicrobials. AI-2 is a particularly attractive candidate for such studies because of its widespread use in the microbial kingdom.