Multiple system atrophy/progressive supranuclear palsy:: α-Synuclein, synphilin, tau, and APOE
Multiple system atrophy/progressive supranuclear palsy:: α-Synuclein, synphilin, tau, and APOE
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DOI：
10.1212/wnl.55.12.1918
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发表时间：
2000-12-26
期刊：
影响因子：
9.9
通讯作者：
Wood, NW
中科院分区：
文献类型：
--
作者：
Morris, HR;Vaughan, JR;Wood, NW
在多系统萎缩（MSA）和进行性核上性麻痹（PSP）患者和对照组中分析了α突触核蛋白、tau蛋白、突触亲蛋白和APOE基因型。证实了tau插入多态性对PSP发展的易感作用。然而，α-突触核蛋白、亲突触蛋白或APOE变异性对PSP的发生没有影响，tan、α-突触核蛋白、APOE或亲突触蛋白基因变异性对MSA的发生没有影响.
Alpha synuclein, tau, synphilin, and APOE genotypes were analyzed in patients with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and controls. The predisposing effect of the tau insertion polymorphism to the development of PSP is confirmed. However, no effect of alpha -synuclein, synphilin, or APOE variability on the development of PSP, or of tan, alpha -synuclein, APOE, or synphilin gene variability on the development of MSA, are demonstrated.