Reciprocal glycerolipid syntheses in skeletal muscle of obese rats.
Reciprocal glycerolipid syntheses in skeletal muscle of obese rats.
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肥胖大鼠骨骼肌中甘油脂的相互合成。
DOI：
10.1055/s-2005-921143
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Guo,ZK
中科院分区：
文献类型：
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作者：
Guo,ZK
已知肥胖和 2 型糖尿病患者骨骼肌中的肌细胞内甘油三酯 (imcTG) 水平异常高，而过量的 imcTG 是胰岛素抵抗的有力预测因子 [1±3]。另一方面，imcTG 过量积累的途径仍然未知。由于合成是 imcTG 积累的第一步，因此肥胖时 imcTG 的合成可能会加速。同时，由于甘油是甘油三酯和磷脂合成的常见前体，因此imcTG合成的增加也可能影响磷脂代谢。基于我们之前的发现，即甘油是禁食大鼠中 imcTG 合成的主要前体，我们使用高脂喂养的大鼠肥胖模型和 14C- 甘油作为示踪剂测试了这一假设 [4]。
Intramyocellular triglyceride (imcTG) levels in skeletal muscle are known to be abnormally high in obesity and type 2 diabetes, and excess imcTG is a strong predictor of insulin resistance [1±3]. On the other hand, the pathways underlying excess imcTG ac− cumulation remain unknown. Since synthesis is the initial step in imcTG accumulation, imcTG synthesis may be accelerated in obesity. Meanwhile, since glycerol is a common precursor in the synthesis of both triglycerides and phospholipids, increased imcTG synthesis may also affect the phospholipid metabolism. We have tested the hypothesis using the high− fat− fed rat obesity model and 14C− glycerol as a tracer based on our previous findings that glycerol is the main precursor for imcTG synthesis in fasted rats [4].