Lipid-lowering effect of polyunsaturated fatty acids in hemodialysis patients.
Lipid-lowering effect of polyunsaturated fatty acids in hemodialysis patients.
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DOI：
10.1053/jren.2000.16326
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发表时间：
2000-10-01
期刊：
影响因子：
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通讯作者：
Khajehdehi, P
中科院分区：
文献类型：
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作者：
Khajehdehi, P
在这项随机、安慰剂对照试验中，研究了富含多不饱和脂肪酸的鱼油和玉米油与以饱和芝麻油为主的60例血液透析患者的安全性和降脂效果。每组(n=15)每天服用鱼油(1.5g)、玉米油(4.5g)、芝麻油(4.5g)或安慰剂。分别于治疗前和治疗2个月后检测血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇。经鱼油、玉米油治疗后，血清高密度脂蛋白胆固醇显著升高，低密度脂蛋白胆固醇显著降低。此外，补充鱼油后血清甘油三酯显著降低。鱼和玉米油治疗后，低密度脂蛋白胆固醇/高密度脂蛋白胆固醇、总胆固醇/高密度脂蛋白胆固醇、甘油三酯/高密度脂蛋白胆固醇的比值显著降低。芝麻油对血液透析患者的血脂无明显影响。我们的结果表明，短期小剂量补充多不饱和脂肪酸对血液透析患者的血脂异常是安全和有益的。
In this randomized and placebo-controlled trial, safety and lipid-lowering effect of fish and corn oils rich in polyunsaturated fatty acids compared with sesame oil that is mainly saturated were studied in 60 hemodialysis cases allocated to 4 different treatment groups. Each group (n = 15) received either fish oil (1.5 g), corn oil (4.5 g), sesame oil (4.5 g), or placebo, daily. Serum triglyceride, cholesterol, low density lipoprotein cholesterol (LDL-c), and high density lipoprotein cholesterol (HDL-c) were measured before and after 2 months of therapy. Serum HDL-c increased, but LDL-c decreased significantly after fish and corn oil therapy. In addition, serum triglyceride decreased significantly after supplementary fish oil. The ratios of LDL-c to HDL-c, total cholesterol to HDL-c, and triglyceride to HDL-c decreased significantly after fish and corn oil therapy. Sesame oil had no significant effect on the lipid profile of hemodialysis patients. Our results suggest that short-term low-dose supplementary polyunsaturated fatty acids are safe and beneficial for the lipid abnormalities of hemodialysis patients.