C-type lectin-like proteins from snake venoms
C-type lectin-like proteins from snake venoms
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DOI：
10.1016/j.toxicon.2012.03.001
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发表时间：
2012-09-15
期刊：
影响因子：
2.8
通讯作者：
Eble, Johannes A.
中科院分区：
文献类型：
--
作者：
Arlinghaus, Franziska T.;Eble, Johannes A.
蛇毒中的C型凝集素样蛋白（CTL）具有多种生理功能。它们在止血中发挥作用，并有助于阐明血液凝固和血小板活化的机制。它们的基本结构由亚基α和β组成，它们通过典型的结构域交换基序形成异二聚体。这些异二聚体可以形成寡聚体，如四聚体的黄酮素-A和惊厥素，它们排列成环状结构。Rhocaltin是一种选择性α 2 β 1整联蛋白拮抗剂，由四个不同的亚基组成，形成一种新的十字形结构。沿着EMS 16和VP 12，rhoclitin抑制胶原与α 2A结构域的结合。这些整合素特异性拮抗剂是开发抗转移和抗血管生成药物的主要结构。(c)2012爱思唯尔有限公司保留所有权利。
C-type lectin-like proteins (CTLs) as found in snake venoms fulfill various physiological functions. They play a role in hemostasis and have helped elucidate mechanisms involved in blood coagulation and platelet activation. Their basic structure consists of the subunits alpha and beta, which form heterodimers via a typical domain-swapping motif. These heterodimers can form oligomers such as the tetrameric flavocetin-A and convulxin, which arrange into cyclic structures. Rhodocetin is a selective alpha 2 beta 1 integrin antagonist consisting of four distinct subunits forming a novel cruciform structure. Along with EMS16 and VP12, rhodocetin inhibits collagen-binding to the alpha 2A-domain. These integrin-specific antagonists are lead structures for the development of antimetastatic and antiangiogenic drugs. (c) 2012 Elsevier Ltd. All rights reserved.